Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 4/20 | 0.33 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.32 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 3/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | GRK2 | P25098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966156 | 0.91 | KCNH2 (0.37) | SLC6A9CYP2D6CYP3A4KCNH2SLC6A5 | |
| SCHEMBL14965763 | 0.90 | MITF (0.34) | MITFLMNAKCNH2 | |
| SCHEMBL14965539 | 0.87 | NR1H3 (0.39) | MITFNR1D1NR1H3 | |
| SCHEMBL14965901 | 0.86 | MITF (0.37) | MITFCYP2D6LMNA | |
| SCHEMBL14971075 | 0.84 | MEP1B (0.38) | MEP1BMITFPPARAPPARDALKBH1 | |
| SCHEMBL14965734 | 0.83 | NR1D1 (0.38) | MITFNR1D1NR1H3LMNA | |
| SCHEMBL14969412 | 0.82 | NR1D1 (0.36) | MITFNR1D1NR1H3KCNH2 | |
| SCHEMBL14966100 | 0.82 | KCNH2 (0.40) | MITFKCNH2 | |
| SCHEMBL14969684 | 0.82 | NR1D1 (0.36) | MITFNR1D1LMNA | |
| SCHEMBL14965850 | 0.79 | MITF (0.35) | MITFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |