Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | Q9HBH1 | 1/20 | 0.42 | |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18738463 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2KLKB1PLGPDFSPHK1 | |
| SCHEMBL29335395 | 0.84 | KLKB1 (0.43) | KLKB1PLGPDFSPHK1SPHK2 | |
| SCHEMBL20864042 | 0.83 | LTA4H (0.40) | KLKB1PLGPDFSPHK1ROCK1 | |
| SCHEMBL24864663 | 0.81 | KLKB1 (0.48) | KLKB1PLGPDFSPHK1SPHK2 | |
| SCHEMBL24539700 | 0.80 | C3AR1 (0.42) | SMN1; SMN2MEN1KMT2AKLKB1PLG | |
| SCHEMBL24864484 | 0.80 | KLKB1 (0.47) | KLKB1PLGPDFSPHK1SPHK2 | |
| SCHEMBL24701258 | 0.80 | C3AR1 (0.42) | SMN1; SMN2MEN1KMT2AKLKB1PLG | |
| SCHEMBL17067271 | 0.80 | KLKB1 (0.47) | SMN1; SMN2KLKB1PLGPDFSPHK1 | |
| SCHEMBL17637516 | 0.80 | LTA4H (0.56) | SPHK1ROCK1MYLK4SPHK2LTA4H | |
| SCHEMBL17661962 | 0.80 | LTA4H (0.56) | SPHK1ROCK1MYLK4SPHK2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493853-A1 | HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES | Pfizer Inc (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018025168-A1 | HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2018-02-08 | — | — | WO | disclosed |
| EP-2917195-A1 | SPLICEOSTATIN ANALOGS | Pfizer Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| EP-2780039-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2014068443-A1 | SPLICEOSTATIN ANALOGS | PFIZER INC. (US) | 2014-05-08 | — | — | WO | disclosed |
| WO-2013072813-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. (US) | 2013-05-23 | — | — | WO | disclosed |