Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965927 | 0.93 | ALDH1A1 (0.52) | LMNARAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL14966152 | 0.90 | ALDH1A1 (0.51) | LMNARAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL14965777 | 0.87 | HIF1A (0.58) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL14966245 | 0.85 | MEN1 (0.53) | LMNARAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL14969456 | 0.85 | POLB (0.43) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL14965982 | 0.85 | HIF1A (0.47) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL14965794 | 0.84 | NPC1 (0.59) | RAB9ASMN1; SMN2TP53NPC1ALDH1A1 | |
| SCHEMBL14965858 | 0.83 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL14969415 | 0.82 | HRH3 (0.42) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL14965916 | 0.82 | ABL1 (0.56) | LMNARAB9ASMN1; SMN2TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |