Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966331 | 0.92 | LMNA (0.45) | POLBALDH1A1CCR1MAPTKMT2A | |
| SCHEMBL14966219 | 0.90 | CA1 (0.48) | POLBALDH1A1ATG4BUSP2HTT | |
| SCHEMBL14965849 | 0.88 | CHRM1 (0.44) | POLBUSP2HTT | |
| SCHEMBL14966065 | 0.87 | LMNA (0.54) | POLBALDH1A1MAPTL3MBTL1TSHR | |
| SCHEMBL14965929 | 0.85 | USP2 (0.39) | POLBALDH1A1USP2HTTKMT2A | |
| SCHEMBL14966242 | 0.85 | LMNA (0.44) | POLBALDH1A1MAPTL3MBTL1TSHR | |
| SCHEMBL14965968 | 0.85 | LMNA (0.48) | ALDH1A1LMNA | |
| SCHEMBL14965548 | 0.83 | CHRM1 (0.52) | USP2HTTKMT2A | |
| SCHEMBL14965565 | 0.82 | KMT2A (0.43) | ALDH1A1USP2HTTMAPTL3MBTL1 | |
| SCHEMBL14965644 | 0.81 | CA1 (0.46) | POLBALDH1A1HTTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |