Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966262 | 0.92 | POLB (0.49) | LMNAKMT2APOLBMAPTALDH1A1 | |
| SCHEMBL14966138 | 0.87 | NAMPT (0.43) | LMNAMEN1KMT2AALDH1A1PARP1 | |
| SCHEMBL14966065 | 0.85 | LMNA (0.54) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL14966242 | 0.84 | LMNA (0.44) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL14965968 | 0.84 | LMNA (0.48) | LMNAALDH1A1CNR1KDM4E | |
| SCHEMBL14966219 | 0.83 | CA1 (0.48) | KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL14965849 | 0.80 | CHRM1 (0.44) | POLB | |
| SCHEMBL14965644 | 0.80 | CA1 (0.46) | LMNAKMT2APOLBALDH1A1 | |
| SCHEMBL14966114 | 0.78 | KCNH2 (0.38) | LMNAPOLBMAPTALDH1A1KDM4E | |
| SCHEMBL14965599 | 0.78 | KDM4E (0.45) | LMNAKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |