Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966442 | 0.92 | KLKB1 (0.41) | PPARGPPARAKLKB1ITGB3ITGB1 | |
| SCHEMBL14966342 | 0.89 | RAB9A (0.43) | MEN1KMT2AKLKB1ITGB3ITGB1 | |
| SCHEMBL14966659 | 0.85 | LMNA (0.48) | PPARGPPARAMEN1KMT2AKLKB1 | |
| SCHEMBL14967198 | 0.84 | SLC6A5 (0.44) | MEN1KMT2AKLKB1HTTSMN1; SMN2 | |
| SCHEMBL14967341 | 0.83 | MEN1 (0.40) | MEN1KMT2AKLKB1MAPK1HTT | |
| SCHEMBL14966991 | 0.82 | LMNA (0.48) | MEN1KMT2AKLKB1RXFP1SMN1; SMN2 | |
| SCHEMBL14966625 | 0.81 | SMN1; SMN2 (0.43) | MEN1KMT2AKLKB1HTTSMN1; SMN2 | |
| SCHEMBL14966965 | 0.81 | NPC1 (0.47) | MEN1KMT2AKLKB1SMN1; SMN2 | |
| SCHEMBL14966647 | 0.81 | SCN9A (0.44) | PPARGPPARAMMP13SMN1; SMN2 | |
| SCHEMBL14966551 | 0.80 | MEN1 (0.40) | PPARAMEN1KMT2AKLKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |