Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967198 | 0.91 | SLC6A5 (0.44) | MEN1KMT2APOLBSMN1; SMN2HTT | |
| SCHEMBL14966442 | 0.85 | KLKB1 (0.41) | SMN1; SMN2HTTCASRSLC6A5RAB9A | |
| SCHEMBL14966827 | 0.83 | SMN1; SMN2 (0.43) | MEN1KMT2APOLBSMN1; SMN2HTT | |
| SCHEMBL14966342 | 0.83 | RAB9A (0.43) | MEN1KMT2ASMN1; SMN2RAB9AHPGD | |
| SCHEMBL14966552 | 0.83 | PPARG (0.40) | MEN1KMT2ASMN1; SMN2HTTKLKB1 | |
| SCHEMBL14966659 | 0.81 | LMNA (0.48) | MEN1KMT2APOLBSMN1; SMN2RAB9A | |
| SCHEMBL14967152 | 0.81 | KDM4E (0.43) | MEN1KMT2ASMN1; SMN2HTTRAB9A | |
| SCHEMBL14966625 | 0.81 | SMN1; SMN2 (0.43) | MEN1KMT2ASMN1; SMN2HTTRAB9A | |
| SCHEMBL14966646 | 0.80 | KLKB1 (0.46) | SMN1; SMN2HTTHPGDKLKB1LMNA | |
| SCHEMBL14966404 | 0.80 | KLKB1 (0.41) | SMN1; SMN2HTTRAB9AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |