Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148112 | 0.88 | PKM (0.72) | PKML3MBTL1MAPK1TSHRTP53 | |
| SCHEMBL14967365 | 0.85 | NR4A2 (0.73) | PKML3MBTL1MAPK1TSHRTP53 | |
| SCHEMBL5390756 | 0.85 | PKM (0.73) | PKMMAPK1TSHRTP53SRD5A2 | |
| SCHEMBL4327125 | 0.85 | PKM (0.73) | PKMMAPK1TSHRTP53SRD5A2 | |
| SCHEMBL14967260 | 0.84 | MAPT (0.68) | PPARDPPARAL3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL14173881 | 0.84 | KCNH2 (0.65) | PPARDPPARAL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL4374627 | 0.84 | NR4A2 (0.71) | PKMPPARDPPARAMAPK1TSHR | |
| SCHEMBL16550312 | 0.83 | RXRA (0.76) | MAPK1SMN1; SMN2ALDH1A1SRD5A2PLA2G4B | |
| SCHEMBL6520330 | 0.83 | RXRA (0.76) | MAPK1SMN1; SMN2ALDH1A1SRD5A2PLA2G4B | |
| SCHEMBL834837 | 0.83 | BCL2 (0.53) | PKMMAPK1TSHRTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |