Sugi Predict

Sugi Predict / Compounds / SCHEMBL14967178

SCHEMBL14967178

SCHEMBL14967178

Cc1cc(=O)c(C#N)c(N)o1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 11/20 0.43
▸ ALDH1A1 P00352 10/20 0.43
▸ MAPT P10636 8/20 0.43
▸ HSD17B10 Q99714 7/20 0.43
▸ ALOX15 P16050 6/20 0.43
▸ HPGD P15428 5/20 0.43
▸ APOBEC3G Q9HC16 1/20 0.43
▸ NQO1 P15559 1/20 0.37
▸ HSD17B3 P37058 1/20 0.34
▸ KMT2A Q03164 6/20 0.34
▸ MEN1 O00255 5/20 0.33
▸ TDP1 Q9NUW8 3/20 0.33
▸ GAA P10253 3/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ UPP1 Q16831 1/20 0.33
▸ RECQL P46063 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA9 Q16790 1/20 0.33
▸ PKM P14618 2/20 0.33
▸ ALOX12 P18054 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16075151 0.71 — —
SCHEMBL17221686 0.65 KDM4E (0.41) KDM4EALDH1A1HSD17B10HPGDKMT2A
SCHEMBL441084 0.64 ALDH1A1 (0.37) KDM4EALDH1A1MAPTHSD17B10ALOX15
SCHEMBL18556190 0.64 ALOX15 (0.39) KDM4EALDH1A1MAPTHSD17B10ALOX15
SCHEMBL28749074 0.63 ALOX15 (0.40) KDM4EALDH1A1MAPTHSD17B10ALOX15
SCHEMBL623702 0.62 — —
SCHEMBL15871004 0.60 KDM4E (0.47) KDM4EALDH1A1MAPTHSD17B10ALOX15
SCHEMBL1319785 0.60 MAPT (0.41) KDM4EALDH1A1MAPTHSD17B10ALOX15
SCHEMBL24498784 0.59 LMNA (0.43) KDM4EALDH1A1MAPTHSD17B10ALOX15
SCHEMBL4869723 0.59 ALDH1A1 (0.67) KDM4EALDH1A1MAPTHSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240165121-A1 SUBSTITUTED BENZENE COMPOUNDS EPIZYME INC (US) 2024-05-23 — — US disclosed
US-11642348-B2 Substituted benzene compounds Epizyme, Inc. (US) 2023-05-09 — — US disclosed
US-11642348-B2 Substituted benzene compounds Epizyme, Inc. (US) 2023-05-09 — — US disclosed
US-11642348-B2 Substituted benzene compounds Epizyme, Inc. (US) 2023-05-09 — — US disclosed
US-20210060027-A1 SUBSTITUTED BENZENE COMPOUNDS Epizyme, Inc. 2021-03-04 — — US disclosed
US-20210060027-A1 SUBSTITUTED BENZENE COMPOUNDS Epizyme, Inc. 2021-03-04 — — US disclosed
US-20200361914-A1 SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS Epizyme, Inc. 2020-11-19 — — US disclosed
US-20200361914-A1 SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS Epizyme, Inc. 2020-11-19 — — US disclosed
EP-3725314-A1 SUBSTITUTED BENZENE COMPOUNDS Epizyme, Inc. (US) 2020-10-21 — — EP disclosed
EP-3725314-A1 SUBSTITUTED BENZENE COMPOUNDS Epizyme, Inc. (US) 2020-10-21 — — EP disclosed
WO-2014151142-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. (US) 2014-09-25 — — WO disclosed
WO-2014151142-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. (US) 2014-09-25 — — WO disclosed
US-20140288123-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. 2014-09-25 — — US disclosed
EP-2780014-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF Constellation Pharmaceuticals, Inc. (US) 2014-09-24 — — EP disclosed
WO-2014100646-A1 1,4-PYRIDONE COMPOUNDS Epizyme, Inc. (US) 2014-06-26 — — WO disclosed
WO-2014062733-A2 SUBSTITUTED BENZENE COMPOUNDS Epizyme, Inc. (US) 2014-04-24 — — WO disclosed
WO-2014062733-A2 SUBSTITUTED BENZENE COMPOUNDS Epizyme, Inc. (US) 2014-04-24 — — WO disclosed
WO-2013120104-A2 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2013-08-15 — — WO disclosed
WO-2013075083-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2013-05-23 — — WO disclosed
WO-2013075083-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2013-05-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140288123-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF TET1, TET3, EHMT2 KDM4E 76/4885ALDH1A1 1213/4885MAPT 3877/4885
US-20210060027-A1 SUBSTITUTED BENZENE COMPOUNDS CYP1B1, TP53, VHL KDM4E 711/4885ALDH1A1 358/4885MAPT 4181/4885
US-20240165121-A1 SUBSTITUTED BENZENE COMPOUNDS CYP1B1, TP53, VHL KDM4E 711/4885ALDH1A1 358/4885MAPT 4181/4885
US-20200361914-A1 SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS BCOR, CYP2B6, AHR KDM4E 860/4885ALDH1A1 737/4885MAPT 4625/4885
US-11642348-B2 Substituted benzene compounds CYP1B1, TP53, VHL KDM4E 711/4885ALDH1A1 358/4885MAPT 4181/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.