Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.45 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.44 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967483 | 0.87 | ALDH1A1 (0.49) | PKMGAAALDH1A1KMT2AGCK | |
| SCHEMBL14966277 | 0.85 | MAPT (0.64) | PKMPARP10MAPTRAB9AALDH1A1 | |
| SCHEMBL19313609 | 0.84 | GPBAR1 (0.58) | PKMPARP10MAPTLDHAGPBAR1 | |
| SCHEMBL1122621 | 0.80 | PKM (0.63) | PKMPARP10RAB9AGPBAR1POLB | |
| SCHEMBL27261942 | 0.79 | LDHA (0.50) | RAB9ALDHANR4A1NR4A2NR4A3 | |
| SCHEMBL943063 | 0.79 | PPARG (0.58) | PKMRAB9APOLBNR4A2PLA2G4B | |
| SCHEMBL5390756 | 0.77 | PKM (0.73) | PKMPARP10RAB9ANR4A1NR4A2 | |
| SCHEMBL152571 | 0.76 | P4HA1 (0.53) | MAPTLDHAP4HA1P4HTMALDH1A1 | |
| SCHEMBL1285278 | 0.76 | PKM (1.00) | PKMPARP10MAPTRAB9APOLB | |
| SCHEMBL14966976 | 0.76 | KCNA3 (0.45) | MAPTRAB9APOLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |