Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HAT1 | O14929 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459138 | 0.73 | KDM4E (0.38) | ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL14969067 | 0.73 | MEN1 (0.53) | ALDH1A1HTTSMN1; SMN2MAPTMEN1 | |
| SCHEMBL10823654 | 0.71 | PDE4A (0.38) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL6238938 | 0.70 | KMT2A (0.56) | ALDH1A1HTTRAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL31198448 | 0.70 | KMT2A (0.48) | ALDH1A1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL16863377 | 0.69 | PPARA (0.37) | KDM4E | |
| SCHEMBL10823648 | 0.68 | B3GNT2 (0.46) | ALDH1A1SMN1; SMN2KMT2AKDM4ECYP3A4 | |
| SCHEMBL425896 | 0.68 | SLC9A1 (0.35) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL14967295 | 0.68 | KDM4E (0.39) | ALDH1A1HTTRAB9ASMN1; SMN2MAPT | |
| SCHEMBL10208376 | 0.67 | KDM5A (0.48) | DAOALDH1A1MITFHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780338-A1 | URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS | Cephalon, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013074633-A1 | URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS | CEPHALON, INC. (US) | 2013-05-23 | — | — | WO | disclosed |