SCHEMBL459138

SCHEMBL459138

O=C(O)c1c[nH]c(=O)n(CO)c1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.38
KDM3B Q7LBC6 1/20 0.38
KMT2A Q03164 2/20 0.36
ALDH1A1 P00352 1/20 0.36
SLC9A1 P19634 1/20 0.36
CSNK2A1 P68400 4/20 0.35
CSNK2A2 P19784 3/20 0.35
CSNK2B P67870 3/20 0.35
FPR1 P21462 1/20 0.35
FPR2 P25090 1/20 0.35
DYRK1A Q13627 1/20 0.34
MAPT P10636 1/20 0.33
NAPRT Q6XQN6 1/20 0.32
CYP1A2 P05177 1/20 0.32
HSD17B10 Q99714 1/20 0.32
F7 P08709 1/20 0.32
F3 P13726 1/20 0.32
NOTUM Q6P988 1/20 0.31
PIM3 Q86V86 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10823654 0.84 PDE4A (0.38) KDM4EKDM3BKMT2AALDH1A1SLC9A1
SCHEMBL10823648 0.80 B3GNT2 (0.46) KDM4EKDM3BKMT2AALDH1A1SLC9A1
SCHEMBL425896 0.80 SLC9A1 (0.35) KDM4EKDM3BKMT2AALDH1A1SLC9A1
SCHEMBL19812558 0.75 KDM4E (0.41) KDM4EKDM3BKMT2AALDH1A1CSNK2A1
SCHEMBL7586830 0.73 ALDH1A1 (0.42) KDM4EKDM3BKMT2AALDH1A1CSNK2A1
SCHEMBL14967362 0.73 DAO (0.42) KDM4EKMT2AALDH1A1MAPT
SCHEMBL16863256 0.69 KDM4E (0.41) KDM4EKDM3BKMT2AALDH1A1CSNK2A1
SCHEMBL23882395 0.68 CYP2C19 (0.58) KDM4EKMT2AALDH1A1CSNK2A1CSNK2A2
SCHEMBL9054602 0.67 KDM3B (0.39) KDM4EKDM3BKMT2AALDH1A1CSNK2A1
SCHEMBL14969067 0.65 MEN1 (0.53) KDM4EKMT2AALDH1A1MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 337 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002531470-A 2002-09-24 JP claimed
EP-1163374-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES Syntrix Biochip, Inc. (US) 2001-12-19 EP claimed
WO-2000033084-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES SYNTRIX BIOCHIP, INC. (US) 2000-06-08 WO claimed
WO-2026106695-A1 TARGETED NANOPARTICLES ENCAPSULATING WATER-SOLUBLE THERAPEUTICS, METHODS OF PRODUCTION, AND USE OPTIMEOS LIFE SCIENCES, INC. (US) 2026-05-21 WO disclosed
WO-2026098357-A1 FREEZE-DRIED NUCLEIC ACID-LOADED LIPID NANOPARTICLE AND RECONSTITUTION METHOD THEREOF KUDO BIOTECHNOLOGY, INC. (US) 2026-05-15 WO disclosed
US-20260130987-A1 VACCINATION AGAINST PNEUMOCCOCAL AND COVID-19 INFECTIONS PFIZER INC. (US) 2026-05-14 US disclosed
WO-2026088119-A1 LIPIDATED TLR7/8 MODULATORS AS ADJUVANTS AND USES THEREOF PFIZER INC. (US) 2026-04-30 WO disclosed
US-20260109977-A1 MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION TRILINK BIOTECHNOLOGIES, LLC (US) 2026-04-23 US disclosed
EP-4729614-A1 SYSTEM AND METHOD FOR SEPARATING MRNA Suzhou Abogen Biosciences Co., Ltd. (CN) 2026-04-22 EP disclosed
EP-4728076-A1 METHOD FOR STABILIZING RNA Pfizer Inc. (US) 2026-04-22 EP disclosed
EP-4720094-A1 MUTATED FRAGMENT OF VZV GLYCOPROTEIN E Suzhou Abogen Biosciences Co., Ltd. (CN) 2026-04-08 EP disclosed
WO-2003016499-A2 COMBINATORIAL METHODS FOR INDUCING CANCER CELL DEATH THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2003-02-27 WO disclosed
EP-1163374-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES Syntrix Biochip, Inc. (US) 2001-12-19 EP disclosed
EP-1163520-A1 POROUS COATINGS BEARING LIGAND ARRAYS Syntrix Biochip, Inc. (US) 2001-12-19 EP disclosed
US-6159681-A Light-mediated method and apparatus for the regional analysis of biologic material SYNTRIX BIOCHIP, INC. (US) 2000-12-12 US disclosed
WO-2000033084-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES SYNTRIX BIOCHIP, INC. (US) 2000-06-08 WO disclosed
WO-2000033078-A1 POROUS COATINGS BEARING LIGAND ARRAYS SYNTRIX BIOCHIP, INC. (US) 2000-06-08 WO disclosed
WO-1999061653-A2 LIGHT-MEDIATED REGIONAL ANALYSIS OF BIOLOGIC MATERIAL SYNTRIX BIOCHIP (US) 1999-12-02 WO disclosed
US-5705333-A Peptide-based nucleic acid mimics(PENAMS) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-01-06 US disclosed
WO-1996004000-A1 PEPTIDE-BASED NUCLEIC ACID MIMICS (PENAMs) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109977-A1 MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION RNGTT, RNMT, UPF1 KDM4E 461/4885KDM3B 721/4885KMT2A 1224/4885
US-20260130987-A1 VACCINATION AGAINST PNEUMOCCOCAL AND COVID-19 INFECTIONS SARS1, CD14, PYCARD KDM4E 4744/4885KDM3B 4627/4885KMT2A 4478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.