Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1548941 | 0.89 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL1548447 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL1496808 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL1126945 | 0.79 | TSHR (0.53) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL16040428 | 0.78 | MEN1 (0.57) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL2686964 | 0.77 | TSHR (0.59) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL28782981 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL28049576 | 0.76 | MAPT (0.53) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL29835086 | 0.74 | MAPT (0.51) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL23273490 | 0.73 | MEN1 (0.52) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627652-B1 | PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAE WOONG PHARMA (KR) | 2015-12-16 | — | — | EP | disclosed |
| EP-2264031-B1 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAE WOONG PHARMA (KR) | 2015-04-15 | — | — | EP | disclosed |
| EP-2264031-B1 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAE WOONG PHARMA (KR) | 2015-04-15 | — | — | EP | disclosed |
| EP-2627652-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | Daewoong Pharmaceutical Co., Ltd (KR) | 2013-08-21 | — | — | EP | disclosed |
| US-8362012-B2 | Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2013-01-29 | — | — | US | disclosed |
| US-8362012-B2 | Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2013-01-29 | — | — | US | disclosed |
| US-8362012-B2 | Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2013-01-29 | — | — | US | disclosed |
| EP-1967519-B1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC (JP) | 2012-09-05 | — | — | EP | disclosed |
| WO-2012050380-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2012-04-19 | — | — | WO | disclosed |
| US-8026235-B1 | Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2011-09-27 | — | — | US | disclosed |
| US-8026235-B1 | Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2011-09-27 | — | — | US | disclosed |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | DAEWOONG PHARMACEUTICALS CO., LTD. (KR) | 2011-04-14 | — | — | US | disclosed |
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | DAEWOONG PHARMACEUTICALS CO., LTD. (KR) | 2011-04-14 | — | — | US | disclosed |
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | DAEWOONG PHARMACEUTICALS CO., LTD. (KR) | 2011-04-14 | — | — | US | disclosed |
| US-7906508-B2 | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity | JAPAN TOBACCO INC. (JP) | 2011-03-15 | — | — | US | disclosed |
| EP-2264031-A2 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2010-12-22 | — | — | EP | disclosed |
| EP-2264031-A2 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2010-12-22 | — | — | EP | disclosed |
| EP-1967519-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2008-09-10 | — | — | EP | disclosed |
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | TRPV1, HRH4, TRPV4 | ALDH1A1 333/4885MEN1 4053/4885KMT2A 2498/4885 |
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | ALDH1A1 1012/4885MEN1 4733/4885KMT2A 3492/4885 |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | ALDH1A1 1012/4885MEN1 4733/4885KMT2A 3492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.