Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14968335 | 0.86 | NPC1 (0.46) | HRH3MAOBNPC1RAB9AMEN1 | |
| SCHEMBL14968342 | 0.84 | S1PR1 (0.43) | HRH3MAOBNPC1RAB9AMEN1 | |
| SCHEMBL13784398 | 0.75 | MAOB (0.55) | HRH3MAOBMEN1KMT2A | |
| SCHEMBL4656889 | 0.72 | L3MBTL1 (0.49) | MAOB | |
| SCHEMBL435043 | 0.72 | ALDH1A1 (0.61) | MAOBNPC1RAB9AERN1APP | |
| SCHEMBL21436935 | 0.70 | HDAC8 (0.51) | MAOBNPC1RAB9AAPP | |
| SCHEMBL26549169 | 0.70 | LTA4H (0.51) | MAOB | |
| SCHEMBL14970601 | 0.70 | KDM4E (0.60) | NPC1RAB9AMEN1KMT2AAPP | |
| SCHEMBL7744533 | 0.69 | MAOB (0.51) | MAOBRAB9ACASP3SENP8SENP7 | |
| SCHEMBL2090976 | 0.69 | MAOB (0.62) | MAOBKMT2AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780337-A1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS | Merck Sharp & Dohme Corp. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013074388-A1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |