Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965415 | 0.92 | HTR2A (0.37) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14968826 | 0.81 | MAPT (0.41) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14965413 | 0.72 | HTR2A (0.40) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14746587 | 0.71 | LPL (0.44) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL15360092 | 0.70 | SLC6A4 (0.55) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14965305 | 0.70 | CYP1A2 (0.47) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL328386 | 0.67 | HTR2A (0.48) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL10559362 | 0.67 | SCN9A (0.50) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL15596855 | 0.67 | CYP1A2 (0.47) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14965170 | 0.67 | MAOA (0.57) | KDM4EMEN1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9539253-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150335642-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2015-11-26 | — | — | US | disclosed |
| US-9133131-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140315783-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2014-10-23 | — | — | US | disclosed |
| WO-2013072758-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315783-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | TRPV1, P2RX3, CACNA1A | KDM4E 3543/4885MEN1 3888/4885ALDH1A1 352/4885 |
| US-20150335642-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | TRPV1, P2RX3, CACNA1A | KDM4E 3543/4885MEN1 3888/4885ALDH1A1 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.