Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21104547 | 0.85 | ALDH1A1 (0.52) | MAOAMAOBPDE7AMAPTCYP1A2 | |
| SCHEMBL14965305 | 0.82 | CYP1A2 (0.47) | MAPTCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL10559362 | 0.82 | SCN9A (0.50) | MAPTCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL15360092 | 0.82 | SLC6A4 (0.55) | MAPTCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4374841 | 0.81 | HSPB1 (0.58) | MAOAMAOBMAPTALDH1A1KDM4E | |
| SCHEMBL554810 | 0.81 | MAOA (0.61) | MAOAMAOBPDE7AMAPTCYP1A2 | |
| SCHEMBL765629 | 0.81 | ST14 (0.50) | MAOBMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6826221 | 0.79 | F2 (0.60) | MAPTCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL755813 | 0.79 | ADRB2 (0.50) | MAPTCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL20565912 | 0.79 | MAOA (0.57) | MAOAMAOBPDE7AMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141980-A1 | AGRICULTURAL CHEMICALS | GLOBACHEM NV (BE) | 2019-07-25 | — | — | WO | disclosed |
| US-9539253-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9539253-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9539253-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150335642-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2015-11-26 | — | — | US | disclosed |
| US-20150335642-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2015-11-26 | — | — | US | disclosed |
| US-20150335642-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2015-11-26 | — | — | US | disclosed |
| US-9133131-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133131-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133131-B2 | Pyrimidine diol amides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140315783-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315783-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315783-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2014-10-23 | — | — | US | disclosed |
| WO-2013072758-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072758-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315783-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | TRPV1, P2RX3, CACNA1A | MAOA 1371/4885MAOB 522/4885PDE7A 744/4885 |
| US-20150335642-A1 | PYRIMIDINE DIOL AMIDES AS SODIUM CHANNEL BLOCKERS | TRPV1, P2RX3, CACNA1A | MAOA 1371/4885MAOB 522/4885PDE7A 744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.