Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969499 | 0.87 | CYP4F2 (0.44) | HTR2CSLC6A4ALDH1A1GLSCYP4F2 | |
| SCHEMBL7936706 | 0.85 | HTR2C (0.42) | HTR2CSLC6A4GLSRIPK1KMT2A | |
| SCHEMBL30952689 | 0.85 | HTR2C (0.42) | HTR2CSLC6A4GLSRIPK1KMT2A | |
| SCHEMBL297071 | 0.84 | ALDH1A1 (0.51) | HTR2CSLC6A4ALDH1A1GLSMEN1 | |
| SCHEMBL3109559 | 0.84 | HTR2C (0.41) | HTR2CSLC6A4GLSRIPK1MEN1 | |
| SCHEMBL4180366 | 0.83 | HTR2C (0.42) | HTR2CSLC6A4ALDH1A1GLSCYP4F2 | |
| SCHEMBL3108959 | 0.83 | NR1H4 (0.45) | HTR2CSLC6A4GLSCYP4F2CYP4A11 | |
| SCHEMBL3110201 | 0.82 | GLS (0.43) | HTR2CSLC6A4ALDH1A1GLSHSP90AA1 | |
| SCHEMBL3116212 | 0.82 | LTA4H (0.42) | HTR2CSLC6A4GLSRIPK1NPC1 | |
| SCHEMBL3085983 | 0.82 | SLC6A4 (0.41) | HTR2CSLC6A4ALDH1A1GLSHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |