Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.46 |
| ▸ | BCR | P11274 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965777 | 0.91 | HIF1A (0.58) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14965794 | 0.86 | NPC1 (0.59) | SMN1; SMN2ALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL14965587 | 0.84 | HIF1A (0.60) | ALDH1A1MEN1KMT2AHIF1AEPAS1 | |
| SCHEMBL14966245 | 0.84 | MEN1 (0.53) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14969414 | 0.83 | LMNA (0.53) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14965590 | 0.83 | CHRNB2 (0.45) | ALDH1A1 | |
| SCHEMBL14965927 | 0.83 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14965550 | 0.83 | SLC2A1 (0.39) | SMN1; SMN2ALDH1A1LMNATSHRABL1 | |
| SCHEMBL14966186 | 0.82 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14966152 | 0.82 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |