Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 4/20 | 0.36 |
| ▸ | PRKACG | P22612 | 4/20 | 0.36 |
| ▸ | PRKACB | P22694 | 4/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14971085 | 0.94 | TNIK (0.40) | MEN1GAAGFERKMT2ATNIK | |
| SCHEMBL14971091 | 0.87 | DRD2 (0.44) | MEN1GAAKMT2AFAAHDRD2 | |
| SCHEMBL14969428 | 0.86 | MAP3K11 (0.42) | TNIKMAPK14PIK3CAMTORFAAH | |
| SCHEMBL14966205 | 0.85 | LSS (0.46) | DRD2DRD4DRD3KDM4EALDH1A1 | |
| SCHEMBL14966131 | 0.85 | DRD2 (0.49) | MEN1GAAKMT2ADRD2DRD4 | |
| SCHEMBL14965795 | 0.83 | CYP11B1 (0.45) | DRD2DRD4DRD3 | |
| SCHEMBL14966240 | 0.83 | KIT (0.40) | TNIKDRD2DRD4DRD3 | |
| SCHEMBL14966336 | 0.82 | DRD2 (0.45) | TNIKFAAHADORA2AADORA1DRD2 | |
| SCHEMBL14966082 | 0.81 | FAAH (0.46) | MEN1KMT2ADHODHFAAHKDM4E | |
| SCHEMBL14966085 | 0.81 | FAAH (0.46) | MEN1KMT2ADHODHFAAHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |