Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14971085 | 0.92 | TNIK (0.40) | FLT1MAPK14TNIKAURKBEGFR | |
| SCHEMBL14969448 | 0.86 | MEN1 (0.41) | MAPK14TNIKPIK3CAMTORPRKCQ | |
| SCHEMBL14971108 | 0.84 | ALDH1A1 (0.44) | FAAHALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL14965513 | 0.83 | LSS (0.46) | ALDH1A1LMNAMAPTKCNJ1SMN1; SMN2 | |
| SCHEMBL14965918 | 0.82 | ALDH1A1 (0.37) | KCNH2JAK2ALDH1A1LMNAMAPT | |
| SCHEMBL14965746 | 0.82 | DRD2 (0.41) | KCNH2DRD4ALDH1A1LMNAMAPT | |
| SCHEMBL14966014 | 0.81 | CHRNA7 (0.42) | KCNH2LRRK2FAAHCHEK1ALDH1A1 | |
| SCHEMBL14965626 | 0.81 | LTA4H (0.40) | MAPK1FAAHALDH1A1LMNAMAPT | |
| SCHEMBL14965511 | 0.81 | LTA4H (0.40) | MAPK1FAAHALDH1A1LMNAMAPT | |
| SCHEMBL14966198 | 0.81 | KCNJ1 (0.40) | AURKAALDH1A1LMNAMAPTKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |