Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TACR2 | P21452 | 6/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1482240 | 0.99 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL1497050 | 0.96 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL1497166 | 0.96 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL2383602 | 0.93 | MAPT (0.43) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL1496898 | 0.92 | HDAC3 (0.38) | ALDH1A1KDM4EKMT2AHSD17B10TACR2 | |
| SCHEMBL4234597 | 0.90 | MAPT (0.43) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL1497026 | 0.90 | POLB (0.45) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL4229423 | 0.90 | MAPT (0.42) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL1496988 | 0.88 | SIGMAR1 (0.39) | ALDH1A1L3MBTL1MAPTKDM4EGAA | |
| SCHEMBL1497137 | 0.88 | HDAC3 (0.39) | ALDH1A1KDM4EMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |