SCHEMBL1497010

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1497140	0.95	HDAC1 (0.41)	HIF1AHDAC1HDAC6LMNATHRB
	SCHEMBL7999005	0.94	HDAC3 (0.39)	HIF1AHDAC1HDAC6POLBTSHR
	SCHEMBL7999342	0.93	POLB (0.46)	HIF1APOLBTSHRLMNATHRB
	SCHEMBL7998217	0.89	AVPR1A (0.41)	HIF1AHDAC1HDAC6TLR7NAMPT
	SCHEMBL1497201	0.89	NAMPT (0.45)	POLBTSHRLMNANAMPT
	SCHEMBL1482239	0.88	NAMPT (0.43)	POLBTSHRLMNANAMPT
	SCHEMBL1496917	0.86	SIGMAR1 (0.40)	HIF1AHDAC1HDAC6POLBTSHR
	SCHEMBL1483172	0.86	HIF1A (0.42)	HIF1AHDAC1HDAC2ROCK2ROCK1
	SCHEMBL12250204	0.86	HDAC1 (0.42)	HIF1AHDAC1HDAC6TLR7HDAC2
	SCHEMBL8002846	0.86	NAMPT (0.45)	HIF1APOLBTSHRNAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.