Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496990 | 0.92 | USP2 (0.37) | TSHROPRM1OPRD1NAMPTMAPT | |
| SCHEMBL3835471 | 0.91 | HDAC1 (0.44) | TSHROPRM1OPRD1NAMPTMAPT | |
| SCHEMBL1496915 | 0.91 | USP2 (0.36) | TSHROPRM1OPRD1NAMPTMAPT | |
| SCHEMBL11898574 | 0.89 | TSHR (0.36) | TSHROPRM1OPRD1NAMPTMAPT | |
| SCHEMBL1497035 | 0.89 | ALDH1A1 (0.37) | TSHRMAPTTP53THRBUSP2 | |
| SCHEMBL3835179 | 0.87 | HDAC1 (0.46) | TSHRHDAC1THRBALDH1A1KDM4E | |
| SCHEMBL1496969 | 0.86 | AVPR1A (0.33) | TSHROPRM1OPRD1MAPTTP53 | |
| SCHEMBL2475828 | 0.86 | HDAC1 (0.39) | HDAC1 | |
| SCHEMBL4393220 | 0.85 | HDAC1 (0.39) | HDAC1 | |
| SCHEMBL4232503 | 0.85 | HSD17B10 (0.40) | TSHROPRM1OPRD1NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |