Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 13/20 | 0.54 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | F13A1 | P00488 | 4/20 | 0.46 |
| ▸ | TGM1 | P22735 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.41 |
| ▸ | CDK14 | O94921 | 2/20 | 0.40 |
| ▸ | CCNY | Q8ND76 | 2/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12265208 | 0.90 | THRA (0.63) | TGM2THRATHRBF13A1TGM1 | |
| SCHEMBL16653882 | 0.77 | TGM2 (0.59) | TGM2THRATHRBF13A1TGM1 | |
| Trifluoroacetic Acid SCHEMBL30182563 | 0.77 | HDAC3 (0.46) | ITGB3ITGB1ITGAVITGA5 | |
| Trifluoroacetic Acid SCHEMBL29803202 | 0.76 | NR1H4 (0.53) | LMNA | |
| SCHEMBL8867192 | 0.76 | THRA (0.65) | TGM2THRATHRBF13A1TGM1 | |
| SCHEMBL8867209 | 0.76 | THRA (0.65) | TGM2THRATHRBF13A1TGM1 | |
| Trifluoroacetic Acid SCHEMBL30182723 | 0.75 | TAAR1 (0.52) | ITGB3ITGB1ITGAVITGA5ITGB2 | |
| SCHEMBL12832351 | 0.74 | THRB (0.77) | TGM2THRATHRBF13A1TGM1 | |
| Trifluoroacetic Acid SCHEMBL7859231 | 0.74 | TAAR1 (0.67) | — | |
| Tyramine SCHEMBL6433562 | 0.74 | TAAR1 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475375-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-09-22 | — | — | US | disclosed |
| WO-2011031896-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | PIK3CA, PIK3CB, PIK3C2B | TGM2 2927/4885THRA 3800/4885THRB 2282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.