Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17714325 | 0.81 | KDM4E (0.43) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL17725598 | 0.79 | CDK5 (0.51) | NPC1RAB9ACCNB2CDK1CCNB1 | |
| SCHEMBL20516529 | 0.79 | RIPK2 (0.47) | ALDH1A1NPC1RAB9ANPY5RPKM | |
| SCHEMBL17714318 | 0.79 | RIPK2 (0.55) | ALDH1A1KDM4ECYP19A1NPC1RAB9A | |
| SCHEMBL20516533 | 0.77 | RIPK2 (0.40) | ALDH1A1KDM4ESMN1; SMN2CCNB2CDK1 | |
| SCHEMBL17725681 | 0.76 | CDK2 (0.50) | MEN1KMT2ANPC1RAB9ACCNB2 | |
| SCHEMBL22467501 | 0.76 | KDM4E (0.49) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL20516555 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL16793646 | 0.75 | TTK (0.48) | MAPTMAPK1 | |
| SCHEMBL15021642 | 0.74 | PTGES (0.45) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212652-B1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK (CA) | 2021-02-17 | — | — | EP | disclosed |
| EP-3212652-B1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK (CA) | 2021-02-17 | — | — | EP | disclosed |
| US-10875863-B2 | RIPK2 inhibitors and method of treating cancer with same | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-29 | — | — | US | disclosed |
| US-10875863-B2 | RIPK2 inhibitors and method of treating cancer with same | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-29 | — | — | US | disclosed |
| US-20190225617-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2019-07-25 | — | — | US | disclosed |
| US-20190225617-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2019-07-25 | — | — | US | disclosed |
| US-10239881-B2 | RIPK2 inhibitors and method of treating cancer with same | UNIVERSITY HEALTH NETWORK (CA) | 2019-03-26 | — | — | US | disclosed |
| US-10239881-B2 | RIPK2 inhibitors and method of treating cancer with same | UNIVERSITY HEALTH NETWORK (CA) | 2019-03-26 | — | — | US | disclosed |
| US-20180282335-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2018-10-04 | — | — | US | disclosed |
| EP-3212652-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | University Health Network (CA) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016065461-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2016-05-06 | — | — | WO | disclosed |
| WO-2016065461-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2016-05-06 | — | — | WO | disclosed |
| WO-2013078254-A1 | BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282335-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | RIPK2, RIPK1, RIPK4 | ALDH1A1 4547/4885KDM4E 2275/4885MEN1 1368/4885 |
| US-10875863-B2 | RIPK2 inhibitors and method of treating cancer with same | RIPK2, RIPK1, RIPK4 | ALDH1A1 4540/4885KDM4E 2441/4885MEN1 1503/4885 |
| US-10239881-B2 | RIPK2 inhibitors and method of treating cancer with same | RIPK2, RIPK1, RIPK4 | ALDH1A1 4547/4885KDM4E 2275/4885MEN1 1368/4885 |
| US-20190225617-A1 | RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | RIPK2, RIPK1, RIPK4 | ALDH1A1 4540/4885KDM4E 2441/4885MEN1 1503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.