Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.92 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pumosetrag SCHEMBL1299656 | 0.96 | HTR3A (1.00) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| Pumosetrag SCHEMBL1299660 | 0.96 | HTR3A (1.00) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| Pumosetrag SCHEMBL390615 | 0.96 | HTR3A (1.00) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| Pumosetrag SCHEMBL1497905 | 0.95 | HTR3A (0.98) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| Pumosetrag SCHEMBL29406201 | 0.95 | HTR3A (0.98) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| Pumosetrag SCHEMBL1497908 | 0.95 | HTR3A (0.98) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| Pumosetrag SCHEMBL1299759 | 0.94 | HTR3A (0.96) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| SCHEMBL1497911 | 0.89 | HTR3A (0.86) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| SCHEMBL1497977 | 0.81 | HTR3A (0.72) | HTR3ACYP3A4CHRNA7HTR3EHTR3B | |
| SCHEMBL1497936 | 0.75 | HTR3A (0.58) | HTR3ACYP3A4HTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897614-B2 | Preventive agent/remedial agent for constipation predominant IBS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-03-01 | — | — | US | disclosed |
| US-20100210679-A1 | PREVENTIVE AND THERAPEUTIC MEDICAMENT FOR GASTROESOPHAGEAL REFLUX DISEASE | YAMAZAKI SATOSHI | 2010-08-19 | — | — | US | disclosed |
| US-20100204267-A1 | Preventive and therapeutic medicament for gastroesophageal reflux disease | YAMAZAKI SATOSHI | 2010-08-12 | — | — | US | disclosed |
| US-20100168157-A1 | PREVENTIVE AND THERAPEUTIC MEDICAMENT FOR GASTROESOPHAGEAL REFLUX DISEASE | YAMAZAKI SATOSHI | 2010-07-01 | — | — | US | disclosed |
| EP-1829543-B1 | Preventive agent/remedial agent for constipation predominant IBS | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-20080293762-A1 | Preventive and Therapeutic medicament for gastroesophageal reflux disease | EDUSA PHARMACEUTICALS, INC. | 2008-11-27 | — | — | US | disclosed |
| EP-1829543-A1 | Preventive agent/remedial agent for constipation predominant IBS | MITSUBISHI PHARMA CORPORATION (JP) | 2007-09-05 | — | — | EP | disclosed |
| EP-1419772-B1 | PREVENTIVE AGENT/REMEDIAL AGENT FOR CONSTIPATION PREDOMINANT IBS | MITSUBISHI PHARMA CORP (JP) | 2007-07-25 | — | — | EP | disclosed |
| EP-1256581-B1 | PREVENTIVE OR THERAPEUTIC AGENTS FOR GASTRIC OR ESOPHAGEAL REGURGITATION | MITSUBISHI PHARMA CORP (JP) | 2007-03-28 | — | — | EP | disclosed |
| US-20070004770-A1 | Preventive agent/remedial agent for constipation predominant IBS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-01-04 | — | — | US | disclosed |
| US-20060281781-A1 | Preventive and therapeutic medicament for gastroesophageal reflux disease | EDUSA PHARMACEUTICALS, INC. | 2006-12-14 | — | — | US | disclosed |
| US-20050282852-A1 | Preventive and therapeutic medicament for gastroesophageal reflux disease | YAMAZAKI SATOSHI | 2005-12-22 | — | — | US | disclosed |
| US-6967207-B2 | Preventive or therapeutic agents for gastric or esophageal regurgitation | MITSUBISHI PHARMA CORPORATION (JP) | 2005-11-22 | — | — | US | disclosed |
| US-20040248927-A1 | Preventive agent/remedial agent for constipation predominant ibs | MITSUBISHI PHARMA CORPORATION (JP) | 2004-12-09 | — | — | US | disclosed |
| US-20030130304-A1 | Preventive or therapeutic agents for gastric or esophageal regurgitation | MITSUBISHI PHARMA CORPORATION (JP) | 2003-07-10 | — | — | US | disclosed |
| EP-1256581-A1 | PREVENTIVE OR THERAPEUTIC AGENTS FOR GASTRIC OR ESOPHAGEAL REGURGITATION | Mitsubishi Pharma Corporation (JP) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168157-A1 | PREVENTIVE AND THERAPEUTIC MEDICAMENT FOR GASTROESOPHAGEAL REFLUX DISEASE | HRH2, SLC10A2, GRPR | HTR3A 798/4885CYP3A4 985/4885CHRNA7 1794/4885 |
| US-20040248927-A1 | Preventive agent/remedial agent for constipation predominant ibs | BRS3, SLC10A2, FABP2 | HTR3A 25/4885CYP3A4 2819/4885CHRNA7 722/4885 |
| US-20070004770-A1 | Preventive agent/remedial agent for constipation predominant IBS | SLC10A2, FABP2, SI | HTR3A 70/4885CYP3A4 2927/4885CHRNA7 533/4885 |
| US-20050282852-A1 | Preventive and therapeutic medicament for gastroesophageal reflux disease | HRH2, SLC10A2, GRPR | HTR3A 798/4885CYP3A4 985/4885CHRNA7 1794/4885 |
| US-20100210679-A1 | PREVENTIVE AND THERAPEUTIC MEDICAMENT FOR GASTROESOPHAGEAL REFLUX DISEASE | HRH2, SLC10A2, GRPR | HTR3A 798/4885CYP3A4 985/4885CHRNA7 1794/4885 |
| US-20100204267-A1 | Preventive and therapeutic medicament for gastroesophageal reflux disease | HRH2, SLC10A2, GRPR | HTR3A 798/4885CYP3A4 985/4885CHRNA7 1794/4885 |
| US-20080293762-A1 | Preventive and Therapeutic medicament for gastroesophageal reflux disease | HRH2, SLC10A2, GRPR | HTR3A 798/4885CYP3A4 985/4885CHRNA7 1794/4885 |
| US-20060281781-A1 | Preventive and therapeutic medicament for gastroesophageal reflux disease | HRH2, SLC10A2, GRPR | HTR3A 798/4885CYP3A4 985/4885CHRNA7 1794/4885 |
| US-20030130304-A1 | Preventive or therapeutic agents for gastric or esophageal regurgitation | HRH2, SLC10A2, ABCB11 | HTR3A 2210/4885CYP3A4 1662/4885CHRNA7 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.