SCHEMBL14980269

SCHEMBL14980269

CO[Si](CCCNS(=O)(=O)c1ccc(C)cc1)(OC)OC

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 13/20 0.60
PKM P14618 1/20 0.58
CA12 O43570 1/20 0.57
CA2 P00918 1/20 0.57
CA9 Q16790 1/20 0.57
HTT P42858 2/20 0.56
LMNA P02545 1/20 0.56
HPGD P15428 1/20 0.56
ALOX15 P16050 1/20 0.56
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
MAPT P10636 1/20 0.53
MBTD1 Q05BQ5 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL18553820 0.87 ALDH1A1 (0.51) ALDH1A1PKMCA12CA2CA9
SCHEMBL14150586 0.86 MAPK1 (0.65) ALDH1A1PKMHTTLMNANPSR1
SCHEMBL10312376 0.84 ALDH1A1 (0.54) ALDH1A1PKMHTTLMNAHPGD
SCHEMBL7201051 0.82 ALDH1A1 (0.86) ALDH1A1PKMCA12CA2CA9
SCHEMBL7094852 0.82 ALDH1A1 (0.79) ALDH1A1PKMCA12CA2CA9
SCHEMBL2616685 0.81 POLB (0.68) ALDH1A1PKMCA12CA2CA9
SCHEMBL7097551 0.80 ALDH1A1 (0.77) ALDH1A1PKMCA12CA2CA9
SCHEMBL7093365 0.80 ALDH1A1 (0.77) ALDH1A1PKMCA12CA2CA9
SCHEMBL7092896 0.80 ALDH1A1 (0.77) ALDH1A1PKMCA12CA2CA9
SCHEMBL7095193 0.80 ALDH1A1 (0.77) ALDH1A1PKMCA12CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140316045-A1 Silicone Resins DOW CORNING CORPORATION (US) 2014-10-23 US disclosed
US-20140316045-A1 Silicone Resins DOW CORNING CORPORATION (US) 2014-10-23 US disclosed
US-20140249257-A1 Silicone Resins Comprising Metallosiloxane DOW CORNING CORPORATION (US) 2014-09-04 US disclosed
US-20140249257-A1 Silicone Resins Comprising Metallosiloxane DOW CORNING CORPORATION (US) 2014-09-04 US disclosed
WO-2013072371-A1 SILICONE RESINS DOW CORNING CORPORATION (US) 2013-05-23 WO disclosed