Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 3/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14980644 | 0.86 | KIF11 (0.42) | ANPEPENPEPPDE2A | |
| SCHEMBL15157757 | 0.83 | SLC6A4 (0.44) | EPHX1MPLAKT1PDE2ASLC6A4 | |
| SCHEMBL8511924 | 0.83 | TRPV3 (0.40) | EPHX1MPLAKT1PDE2AAR | |
| SCHEMBL2397716 | 0.83 | SLC6A4 (0.44) | EPHX1MPLAKT1PDE2ASLC6A4 | |
| SCHEMBL16464215 | 0.83 | TRPV3 (0.40) | EPHX1MPLAKT1PDE2AAR | |
| SCHEMBL8511925 | 0.83 | TRPV3 (0.40) | EPHX1MPLAKT1PDE2AAR | |
| SCHEMBL297430 | 0.83 | SLC6A4 (0.44) | EPHX1MPLAKT1PDE2ASLC6A4 | |
| SCHEMBL14981099 | 0.81 | IDO1 (0.45) | ANPEPENPEPRPS6KB1 | |
| SCHEMBL2399594 | 0.80 | CTSS (0.36) | EPHX1MPLAKT1SLC6A4AR | |
| SCHEMBL14981093 | 0.80 | ANPEP (0.44) | ANPEPENPEPDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2411397-B1 | ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2411396-B1 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2411395-B1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-05-29 | — | — | EP | disclosed |