Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14142191 | 0.78 | ADRB2 (0.52) | ADRB2SCN4ASLC6A4IDO1TDO2 | |
| SCHEMBL1953110 | 0.78 | ADRB2 (0.52) | ADRB2SCN4ASLC6A4TSHRSLC6A3 | |
| SCHEMBL393010 | 0.76 | ADRB2 (0.50) | ADRB2SCN4ASLC6A4IDO1TDO2 | |
| SCHEMBL14981127 | 0.76 | ANPEP (0.40) | ANPEPADRB2SCN4AIDO1TDO2 | |
| SCHEMBL19134392 | 0.76 | ANPEP (0.53) | ANPEPMAPK1ENPEP | |
| Hydrochloric Acid SCHEMBL25367507 | 0.76 | ADRB2 (0.50) | ADRB2SCN4ASLC6A4IDO1TDO2 | |
| SCHEMBL14980666 | 0.76 | ANPEP (0.53) | ANPEPSLC6A4IDO1TDP1ENPEP | |
| SCHEMBL1977034 | 0.76 | SLC6A4 (0.57) | ADRB2SCN4ASLC6A4IDO1TDO2 | |
| SCHEMBL390989 | 0.76 | SLC6A4 (0.57) | ADRB2SCN4ASLC6A4IDO1TDO2 | |
| SCHEMBL1307450 | 0.76 | ADRB2 (0.50) | ADRB2SCN4ASLC6A4IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411393-B1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2014-01-22 | — | — | EP | disclosed |
| EP-2634191-A1 | Process for preparing derivatives of thienopyrimidinedione | Glenmark Pharmaceuticals S.A. (CH) | 2013-09-04 | — | — | EP | disclosed |
| EP-2411396-B1 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2411397-B1 | ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-05-29 | — | — | EP | disclosed |