Sugi Predict

Sugi Predict / Compounds / SCHEMBL393010

SCHEMBL393010

SCHEMBL393010

NC(CO)c1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADRB2 P07550 1/20 0.50
▸ SCN4A P35499 2/20 0.44
▸ CYP2C9 P11712 3/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ CYP2D6 P10635 2/20 0.43
▸ CYP2C19 P33261 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ SLC6A4 P31645 2/20 0.43
▸ AOC3 Q16853 1/20 0.42
▸ IDO1 P14902 1/20 0.41
▸ TDO2 P48775 1/20 0.41
▸ GABBR2 O75899 5/20 0.41
▸ GABBR1 Q9UBS5 5/20 0.41
▸ LMNA P02545 3/20 0.41
▸ TSHR P16473 2/20 0.41
▸ CYP1A2 P05177 2/20 0.41
▸ THRB P10828 2/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ ADORA3 P0DMS8 1/20 0.41
▸ NFKB1 P19838 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1308806 1.00 ADRB2 (0.50) ADRB2SCN4ACYP2C9MEN1CYP2D6
SCHEMBL1307450 1.00 ADRB2 (0.50) ADRB2SCN4ACYP2C9MEN1CYP2D6
Hydrochloric Acid SCHEMBL3652140 0.98 ADRB2 (0.48) ADRB2SCN4ACYP2C9MEN1CYP2D6
Hydrochloric Acid SCHEMBL1439141 0.98 ADRB2 (0.48) ADRB2SCN4ACYP2C9MEN1CYP2D6
Hydrochloric Acid SCHEMBL1439138 0.98 ADRB2 (0.48) ADRB2SCN4ACYP2C9MEN1CYP2D6
SCHEMBL1444985 0.87 ANPEP (0.41) SCN4ACYP2D6CYP2C19SLC6A4TSHR
Bromobenzene SCHEMBL27783637 0.85 SCN4A (0.46) ADRB2SCN4ACYP2C9MEN1CYP2D6
SCHEMBL1759807 0.82 CNR1 (0.57) MEN1KMT2ALMNATSHRADORA3
SCHEMBL391358 0.82 ADRB2 (0.46) ADRB2SCN4ACYP2C9MEN1CYP2D6
SCHEMBL16649881 0.82 ADRB2 (0.46) ADRB2SCN4ACYP2C9MEN1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116515782-A Amine dehydrogenase mutant and application thereof in chiral amine alcohol compound synthesis 中国科学院天津工业生物技术研究所 2023-08-01 — — CN claimed
US-20260092057-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-04-02 — — US disclosed
US-12264137-B2 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors VALO HEALTH, INC. (US) 2025-04-01 — — US disclosed
EP-4522154-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-03-19 — — EP disclosed
US-12252495-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2025-03-18 — — US disclosed
EP-3365334-B1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMA CO LTD (JP) 2024-07-17 — — EP disclosed
US-20240109902-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2024-04-04 — — US disclosed
CN-113544131-B Pyrrolo-heterocyclic derivative, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2024-03-15 — — CN disclosed
US-20240052394-A1 BIOPRODUCTION OF ENANTIOPURE (R)- AND (S)-2-PHENYLGLYCINOL FROM STYRENE AND RENEWABLE FEEDSTOCKS VIA ARTIFICIAL ENZYME CASCADE NATIONAL UNIVERSITY OF SINGAPORE (SG) 2024-02-15 — — US disclosed
CN-117229210-A Decahydroisoquinoline compound and preparation method and application thereof 中国科学院上海药物研究所 2023-12-15 — — CN disclosed
US-6982274-B2 1H-indazole compound EISAI CO., LTD. (JP) 2006-01-03 — — US disclosed
US-20050282880-A1 Novel 1H-indazole compounds EISAI R&D MANAGEMENT CO., LTD. (JP) 2005-12-22 — — US disclosed
WO-2005058892-A1 PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS GLAXO GROUP LIMITED (GB) 2005-06-30 — — WO disclosed
US-6838527-B2 Polymer-immobilized α-iminoester JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) 2005-01-04 — — US disclosed
CN-1512987-A Novel 1H-indazole compound ������������ʽ���� 2004-07-14 — — CN disclosed
US-20040127538-A1 Novel 1h-indazole compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2004-07-01 — — US disclosed
EP-1380576-A1 NOVEL 1H-INDAZOLE COMPOUND Eisai Co., Ltd. (JP) 2004-01-14 — — EP disclosed
US-20030187147-A1 Polymer-immobilized alpha-iminoester JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) 2003-10-02 — — US disclosed
EP-1270549-A1 POLYMER-IMMOBILIZED ALPHA-IMINOESTER Japan Science and Technology Corporation (JP) 2003-01-02 — — EP disclosed
US-4695630-A Cycloacetals BAYER AKTIENGESELLSCHAFT (DE) 1987-09-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12252495-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 ADRB2 1451/4885SCN4A 3118/4885CYP2C9 4111/4885
US-20030187147-A1 Polymer-immobilized alpha-iminoester PADI1, ADH1A, IL4I1 ADRB2 989/4885SCN4A 3221/4885CYP2C9 377/4885
US-12264137-B2 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors HDAC1, HDAC4, HDAC2 ADRB2 4587/4885SCN4A 1076/4885CYP2C9 3927/4885
US-20240109902-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 ADRB2 1451/4885SCN4A 3118/4885CYP2C9 4111/4885
US-20040127538-A1 Novel 1h-indazole compound MAPK1, MAPK14, MAPK3 ADRB2 477/4885SCN4A 1442/4885CYP2C9 821/4885
US-20260092057-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF BCL2L2, BCL2A1, BCL2L1 ADRB2 1510/4885SCN4A 1524/4885CYP2C9 1152/4885
US-20050282880-A1 Novel 1H-indazole compounds MAPK1, MAPK3, MAPK13 ADRB2 453/4885SCN4A 1988/4885CYP2C9 923/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.