Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.41 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.41 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11560494 | 0.78 | PPME1 (0.55) | PKML3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL11560496 | 0.78 | PPME1 (0.55) | PKML3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL4172982 | 0.75 | BRAF (0.48) | PKML3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL4172973 | 0.75 | BRAF (0.48) | PKML3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL4172977 | 0.75 | BRAF (0.48) | PKML3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL4071742 | 0.75 | MEN1 (0.55) | ALDH1A1HPGDKDM4EGAASMN1; SMN2 | |
| SCHEMBL3243229 | 0.75 | MEN1 (0.55) | ALDH1A1HPGDKDM4EGAASMN1; SMN2 | |
| SCHEMBL4071741 | 0.75 | MEN1 (0.55) | ALDH1A1HPGDKDM4EGAASMN1; SMN2 | |
| SCHEMBL9163842 | 0.74 | PPME1 (0.58) | PKML3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL8716630 | 0.74 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993634-B2 | Methods and use of compounds that bind to Her2/neu receptor complex | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130190405-A1 | METHODS AND USE OF COMPOUNDS THAT BIND TO HER2/NEU RECEPTOR COMPLEX | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-25 | — | — | US | disclosed |
| US-20130137774-A1 | METHODS AND USE OF COMPOUNDS THAT BIND TO HER2/NEU RECEPTOR COMPLEX | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137774-A1 | METHODS AND USE OF COMPOUNDS THAT BIND TO HER2/NEU RECEPTOR COMPLEX | ERBB2, EGFR, ERBB3 | PKM 2867/4885L3MBTL1 4339/4885ALDH1A1 4106/4885 |
| US-20130190405-A1 | METHODS AND USE OF COMPOUNDS THAT BIND TO HER2/NEU RECEPTOR COMPLEX | ERBB2, EGFR, ERBB3 | PKM 3221/4885L3MBTL1 4423/4885ALDH1A1 3796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.