Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 11/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716590 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MAPTNPSR1KDM4EHPGD | |
| SCHEMBL8716592 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MAPTNPSR1KDM4EHPGD | |
| SCHEMBL8716626 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTNPSR1KDM4EHPGD | |
| SCHEMBL8716686 | 0.74 | ALDH1A1 (0.65) | ALDH1A1MAPTNPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL8716684 | 0.74 | ALDH1A1 (0.65) | ALDH1A1MAPTNPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL14982053 | 0.74 | PKM (0.48) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8716035 | 0.69 | MAPT (0.47) | ALDH1A1MAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL8716034 | 0.69 | MAPT (0.47) | ALDH1A1MAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL29374992 | 0.68 | ALDH1A1 (0.60) | ALDH1A1MAPTNPSR1KDM4EHPGD | |
| SCHEMBL1092518 | 0.68 | ALDH1A1 (0.60) | ALDH1A1MAPTNPSR1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | claimed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | claimed |
| US-5783575-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-07-21 | — | — | US | disclosed |
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | disclosed |
| US-5696148-A | POTENT ANTAGONIST OF METABOTROPIC GLUTAMATE RECEPTORS; TREATING EPILEPSY, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, BRAIN DISORDER AND ALZHEIMER'S DISEASE | NOVO NORDISK A/S (DK) | 1997-12-09 | — | — | US | disclosed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | disclosed |