Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12549799 | 0.79 | KDM4E (0.41) | HTR6ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL30557637 | 0.77 | CYP2A6 (0.47) | HTR6ALDH1A1L3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL31021 | 0.69 | HTR6 (0.73) | HTR6POLBKMT2A | |
| SCHEMBL29509279 | 0.69 | HTR6 (0.73) | HTR6POLBKMT2A | |
| SCHEMBL7174067 | 0.69 | RECQL (0.56) | MAPTTHRBALDH1A1POLBTSHR | |
| SCHEMBL14985297 | 0.68 | MAPT (0.60) | MAPTTHRBALDH1A1POLBTSHR | |
| SCHEMBL30557651 | 0.67 | MMP2 (0.47) | HTR6BRD4CYP11B1CYP11B2 | |
| SCHEMBL23749741 | 0.67 | CHRNB2 (0.59) | ALDH1A1KDM4EL3MBTL1KMT2ADBH | |
| SCHEMBL29767352 | 0.67 | ALDH1A1 (0.49) | MAPTALDH1A1TDP1KDM4EL3MBTL1 | |
| SCHEMBL10415933 | 0.67 | GSK3B (0.50) | MAPTALDH1A1TDP1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078413-A1 | MODULATORS OF LIPID STORAGE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-05-30 | — | — | WO | disclosed |