Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.65 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | MARK3 | P27448 | 2/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.65 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.65 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.65 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.65 |
| ▸ | NQO2 | P16083 | 1/20 | 0.65 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.65 |
| ▸ | CDK9 | P50750 | 1/20 | 0.65 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.65 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.65 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.65 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 4/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13606925 | 0.89 | ROCK2 (0.67) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL13606942 | 0.89 | ROCK2 (0.67) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL14307882 | 0.88 | ROCK2 (0.64) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| Hydrochloric Acid SCHEMBL4897166 | 0.88 | ROCK2 (0.66) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL14990561 | 0.88 | ROCK2 (0.70) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| Hydrochloric Acid SCHEMBL4897175 | 0.88 | ROCK2 (0.66) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL13606931 | 0.88 | ROCK2 (0.64) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL13606929 | 0.88 | ROCK2 (0.64) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL31541 | 0.88 | ROCK2 (0.70) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL13606943 | 0.87 | ROCK2 (0.63) | ROCK2ROCK1PRKCDPLK4MARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540344-B2 | Production method for isoquinoline derivatives and salts thereof | KOWA CO., LTD. (JP) | 2017-01-10 | — | — | US | disclosed |
| US-9045460-B2 | Production method for isoquinoline derivatives and salts thereof | KOWA CO., LTD. (JP) | 2015-06-02 | — | — | US | disclosed |
| US-20150087824-A1 | NOVEL PRODUCTION METHOD FOR ISOQUINOLINE DERIVATIVES AND SALTS THEREOF | KOWA CO., LTD. (JP) | 2015-03-26 | — | — | US | disclosed |
| EP-2818463-A1 | Production method of 1,4-diazepane derivatives | Kowa Co., Ltd. (JP) | 2014-12-31 | — | — | EP | disclosed |
| EP-2610252-A1 | NOVEL PRODUCTION METHOD FOR ISOQUINOLINE DERIVATIVES AND SALTS THEREOF | Kowa Co., Ltd. (JP) | 2013-07-03 | — | — | EP | disclosed |
| US-20130144054-A1 | NOVEL PRODUCTION METHOD FOR ISOQUINOLINE DERIVATIVES AND SALTS THEREOF | KOWA CO., LTD. (JP) | 2013-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130144054-A1 | NOVEL PRODUCTION METHOD FOR ISOQUINOLINE DERIVATIVES AND SALTS THEREOF | NOS2, NOS3, NOS1 | ROCK2 59/4885ROCK1 95/4885PRKCD 2704/4885 |
| US-20150087824-A1 | NOVEL PRODUCTION METHOD FOR ISOQUINOLINE DERIVATIVES AND SALTS THEREOF | NOS2, NOS3, NOS1 | ROCK2 59/4885ROCK1 95/4885PRKCD 2704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.