Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Angiotensin Ii. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 3/20 | 0.83 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.83 |
| ▸ | REN | P00797 | 3/20 | 0.65 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.62 |
| ▸ | ANPEP | P15144 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Angiotensin Ii SCHEMBL13232382 | 0.99 | AGTR2 (0.84) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL1189 | 0.99 | AGTR2 (0.84) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL2566771 | 0.99 | AGTR2 (0.84) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL3465991 | 0.99 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL21267957 | 0.99 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL1585377 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL2183118 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL8898391 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL21408200 | 0.98 | AGTR2 (0.82) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL513519 | 0.98 | AGTR2 (0.82) | AGTR2AGTR1RENLNPEPANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11553960-B2 | Methods for treating patients with catheter-based renal neuromodulation | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2023-01-17 | — | — | US | disclosed |
| US-11179195-B2 | Renal neuromodulation methods and devices for treatment of polycystic kidney disease | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2021-11-23 | — | — | US | disclosed |
| US-20200038102-A1 | METHODS FOR TREATING PATIENTS WITH CATHETER-BASED RENAL NEUROMODULATION | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2020-02-06 | — | — | US | disclosed |
| US-10194979-B1 | Methods for catheter-based renal neuromodulation | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2019-02-05 | — | — | US | disclosed |
| US-10194980-B1 | Methods for catheter-based renal neuromodulation | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2019-02-05 | — | — | US | disclosed |
| US-9980766-B1 | Methods and systems for renal neuromodulation | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2018-05-29 | — | — | US | disclosed |
| US-20180132931-A1 | RENAL NEUROMODULATION METHODS AND SYSTEMS FOR TREATMENT OF HYPERALDOSTERONISM | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2018-05-17 | — | — | US | disclosed |
| US-20180116713-A1 | RENAL NEUROMODULATION METHODS AND DEVICES FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE | MEDTRONIC ARDIAN LUXEMBOURG (LU) | 2018-05-03 | — | — | US | disclosed |
| US-9883909-B2 | Renal neuromodulation methods and systems for treatment of hyperaldosteronism | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2018-02-06 | — | — | US | disclosed |
| US-9827042-B2 | Renal neuromodulation methods and devices for treatment of polycystic kidney disease | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2017-11-28 | — | — | US | disclosed |
| US-20150374437-A1 | RENAL NEUROMODULATION METHODS AND DEVICES FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE | MEDTRONIC ARDIAN LUXEMBOURG (LU) | 2015-12-31 | — | — | US | disclosed |
| US-9192766-B2 | Renal neuromodulation methods and devices for treatment of polycystic kidney disease | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2015-11-24 | — | — | US | disclosed |
| US-20150088111-A1 | RENAL NEUROMODULATION METHODS AND SYSTEMS FOR TREATMENT OF HYPERALDOSTERONISM | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2015-03-26 | — | — | US | disclosed |
| WO-2013134472-A1 | RENAL NEUROMODULATION METHODS AND SYSTEMS FOR TREATMENT OF HYPERALDOSTERONISM | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2013-09-12 | — | — | WO | disclosed |
| US-20130144251-A1 | RENAL NEUROMODULATION METHODS AND DEVICES FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE | MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (LU) | 2013-06-06 | — | — | US | disclosed |