Angiotensin Ii

SCHEMBL2566771

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1

The experimentally established mechanism targets of Angiotensin Ii. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	AGTR1 known ✓	P30556	3/20	0.84

▸	AGTR2	P50052	9/20	0.84

▸	REN	P00797	3/20	0.66

▸	LNPEP	Q9UIQ6	4/20	0.62

▸	ANPEP	P15144	2/20	0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Angiotensin Ii SCHEMBL1189	1.00	AGTR2 (0.84)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL13232382	1.00	AGTR2 (0.84)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL14990505	0.99	AGTR2 (0.83)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL21267957	0.99	AGTR2 (0.83)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL3465991	0.99	AGTR2 (0.83)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL1585377	0.99	AGTR2 (0.83)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL2183118	0.99	AGTR2 (0.83)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL8898391	0.99	AGTR2 (0.83)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL21408200	0.98	AGTR2 (0.82)	AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL513519	0.98	AGTR2 (0.82)	AGTR2AGTR1RENLNPEPANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5958884-A	ADMINISTERING TO A SUBJECT IN NEED OF SUCH TREATMENT, AN EFFECTIVE AMOUNT OF AN AT.SUB.1 SPECIFIC ANGIOTENSIN II ANTAGONIST AND AN ANGIOTENSIN II AGONIST TO DECREASE THE SYMPTOMS OF ERECTILE DYSFUNCTION.	THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US)	1999-09-28	—	—	US	claimed
EP-2384318-A2	COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS	Ardelyx, Inc. (US)	2011-11-09	—	—	EP	disclosed
WO-2010129467-A1	COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR	PLEXXIKON, INC. (US)	2010-11-11	—	—	WO	disclosed
WO-2010078449-A2	COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS	ARDELYX, INC. (US)	2010-07-08	—	—	WO	disclosed
US-6110895-A	APPLYING TO SKIN GRAFT OR UNDERLYING TISSUE ANGIOTENSIN II AND A CARRIER; CONTACTING GRAFT WITH UNDERLYING TISSUE, AND SECURING GRAFT TO TISSUE, WHERE INCORPORATION OF GRAFT INTO TISSUE IS PROMOTED	UNIVERSITY OF SOUTHERN CALIFORNIA (US)	2000-08-29	—	—	US	disclosed
US-5442062-A	Treating hypertension, congestive heart failure	THE UPJOHN COMPANY (US)	1995-08-15	—	—	US	disclosed