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Angiotensin Ii

Angiotensin Ii

SCHEMBL3465991

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O.[Zn]

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1

The experimentally established mechanism targets of Angiotensin Ii. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ AGTR1 known ✓ P30556 3/20 0.83
▸ AGTR2 P50052 9/20 0.83
▸ REN P00797 3/20 0.65
▸ LNPEP Q9UIQ6 4/20 0.62
▸ ANPEP P15144 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Angiotensin Ii SCHEMBL13232382 0.99 AGTR2 (0.84) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL1189 0.99 AGTR2 (0.84) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL2566771 0.99 AGTR2 (0.84) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL14990505 0.99 AGTR2 (0.83) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL21267957 0.99 AGTR2 (0.83) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL1585377 0.98 AGTR2 (0.83) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL2183118 0.98 AGTR2 (0.83) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL8898391 0.98 AGTR2 (0.83) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL21408200 0.98 AGTR2 (0.82) AGTR2AGTR1RENLNPEPANPEP
Angiotensin Ii SCHEMBL513519 0.98 AGTR2 (0.82) AGTR2AGTR1RENLNPEPANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010146164-A1 FLUOROGENIC PEPTIDASE SUBSTRATE ECOLE NORMALE SUPERIEURE DE LYON (FR) 2010-12-23 — — WO disclosed
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