Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14992720 | 0.87 | MAPT (0.56) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL14992107 | 0.84 | MAPT (0.52) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL14993374 | 0.77 | MAPT (0.50) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL9683485 | 0.76 | MAPT (0.60) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL24628522 | 0.75 | ALDH1A1 (0.51) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL6198859 | 0.74 | KAT2B (0.80) | MAPTL3MBTL1ALDH1A1LMNANPC1 | |
| SCHEMBL19278391 | 0.73 | ALDH1A1 (0.56) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL3659532 | 0.73 | LMNA (0.48) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL14407565 | 0.73 | MAPT (0.57) | MAPTL3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL9272900 | 0.73 | KAT2B (0.72) | MAPTL3MBTL1ALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785710-A1 | SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS | ChemoCentryx, Inc. (US) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013082429-A1 | SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2013-06-06 | — | — | WO | disclosed |