SCHEMBL1499359

SCHEMBL1499359

C=C(C)c1cccc(C2(C)CO2)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 8/20 0.38
SLC6A2 P23975 8/20 0.38
CHRNB4 P30926 8/20 0.38
CHRNA3 P32297 8/20 0.38
CHRNA4 P43681 8/20 0.38
SLC6A3 Q01959 8/20 0.38
CHRNA1 P02708 7/20 0.38
CHRNB1 P11230 7/20 0.38
CHRNG P07510 6/20 0.38
CHRND Q07001 6/20 0.38
SLC6A4 P31645 3/20 0.36
TSHR P16473 2/20 0.35
ALDH1A1 P00352 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 2/20 0.33
BACE1 P56817 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6883686 0.82 CHRNB2 (0.34) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL361976 0.80 CHRNB2 (0.39) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL8236077 0.75
SCHEMBL167439 0.73 FURIN (0.43) TSHRL3MBTL1MAPTHTT
SCHEMBL30717245 0.73 CHRNA1 (0.53) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL27783647 0.72 SLC6A3 (0.53) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL12852075 0.72 OPRD1 (0.42) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL27783648 0.72 SLC6A3 (0.53) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL21296558 0.71 SIGMAR1 (0.37) TSHRALDH1A1L3MBTL1KDM4EMAPT
SCHEMBL5737601 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710159-A1 CATALYST COMPONENTS FOR PROPYLENE POLYMERIZATION W. R. Grace & Co. - Conn. (US) 2020-09-23 EP claimed
US-8344079-B2 Molar ratio modifications to larger polyolefin catalysts BASF CORPORATION (US) 2013-01-01 US claimed
JP-2011508053-A 2011-03-10 JP claimed
EP-2242776-A1 MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS BASF Corporation (US) 2010-10-27 EP claimed
WO-2009088596-A1 MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS BASF CATALYSTS LLC (US) 2009-07-16 WO claimed
US-20090171044-A1 MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS BASF CATALYSTS LLC (US) 2009-07-02 US claimed
CN-118339199-A Gas phase process for preparing polypropylene random copolymer 格雷斯公司 2024-07-12 CN disclosed
EP-4396243-A1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION WITH IMPROVED CATALYST PERFORMANCE W.R. GRACE & CO.-CONN. (US) 2024-07-10 EP disclosed
CN-118251425-A Catalyst component for propylene polymerization with improved catalyst performance 格雷斯公司 2024-06-25 CN disclosed
EP-4384556-A1 PROCESS FOR PRODUCING POLYOLEFIN GRANULAR RESIN WITH INCREASED SETTLED BULK DENSITY W. R. Grace & Co.-Conn (US) 2024-06-19 EP disclosed
CN-118055955-A Process for producing polyolefin granular resins with increased settled bulk density 格雷斯公司 2024-05-17 CN disclosed
US-20240043633-A1 POLYPROPYLENE POLYMER FOR PRODUCING BIAXIALLY ORIENTED FILMS AND OTHER ARTICLES W.R. GRACE & CO.-CONN. (US) 2024-02-08 US disclosed
US-11891460-B2 Activated catalyst components for olefin polymerization W. R. GRACE & CO.-CONN. (US) 2024-02-06 US disclosed
US-20040260039-A1 Process for producing organic compound epoxy resin composition, cured article obtained from the epoxy resin, and semiconductor device obtained with epoxy resin MITSUI CHEMICALS, INC. (JP) 2004-12-23 US disclosed
EP-0972776-B1 A phosphine sulfide, a manufacturing process therefor and a use thereof MITSUI CHEMICALS INC (JP) 2003-04-23 EP disclosed
EP-0950649-B1 A process for preparing oxyalkylene derivatives in the presence of phosphine oxides MITSUI CHEMICALS INC (JP) 2003-03-26 EP disclosed
US-6153794-A Phosphine sulfide, a manufacturing process therefor and use thereof MITSUI CHEMICALS, INC. (JP) 2000-11-28 US disclosed
US-6130346-A ESTERIFICATION, CARBONATION, SULFONATION, ETHERIFICATION MITSUI CHEMICALS, INC. (JP) 2000-10-10 US disclosed
EP-0972776-A1 A phosphine sulfide, a manufacturing process therefor and a use thereof Mitsui Chemicals, Inc. (JP) 2000-01-19 EP disclosed
EP-0950649-A1 A process for preparing oxyalkylene derivatives in the presence of phosphine oxides Mitsui Chemicals, Inc. (JP) 1999-10-20 EP disclosed