Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 3/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 4/20 | 0.37 |
| ▸ | RXRB | P28702 | 4/20 | 0.37 |
| ▸ | RXRG | P48443 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 3/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14995543 | 0.85 | RXRA (0.37) | MARS1RXRARXRBRXRGMEN1 | |
| SCHEMBL14995555 | 0.84 | MARS1 (0.64) | MARS1ALDH1A1MEN1KMT2A | |
| SCHEMBL14995435 | 0.81 | RXRA (0.46) | MARS1CACNA1BRXRARXRBRXRG | |
| SCHEMBL3432282 | 0.81 | RXRA (0.52) | MARS1SLC16A3RXRARXRBRXRG | |
| SCHEMBL14995646 | 0.81 | RXRA (0.41) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995358 | 0.80 | MARS1 (0.46) | MARS1SLC16A3RXRARXRBRXRG | |
| SCHEMBL14995626 | 0.79 | RXRA (0.40) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995657 | 0.79 | RXRA (0.43) | MARS1RXRARXRBRXRGMEN1 | |
| SCHEMBL14995581 | 0.78 | RXRA (0.40) | SLC16A3RXRARXRBRXRGMEN1 | |
| SCHEMBL14995389 | 0.78 | RXRA (0.43) | MARS1RXRARXRBRXRGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785705-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013079586-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2013-06-06 | — | — | WO | disclosed |