Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.37 |
| ▸ | RXRB | P28702 | 8/20 | 0.37 |
| ▸ | RXRG | P48443 | 8/20 | 0.37 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MARS1 | P56192 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14995556 | 0.85 | MARS1 (0.45) | RXRARXRBRXRGXPO1KMT2A | |
| SCHEMBL3432282 | 0.84 | RXRA (0.52) | RXRARXRBRXRGKMT2AMEN1 | |
| SCHEMBL15004267 | 0.84 | KMT2A (0.50) | KMT2AMEN1MARS1ATML3MBTL1 | |
| SCHEMBL14995435 | 0.79 | RXRA (0.46) | RXRARXRBRXRGKMT2AMEN1 | |
| SCHEMBL3428855 | 0.79 | PPP1CA (0.50) | RXRARXRBRXRGKMT2AMEN1 | |
| SCHEMBL14995646 | 0.79 | RXRA (0.41) | RXRARXRBRXRGKMT2AMEN1 | |
| SCHEMBL14995657 | 0.79 | RXRA (0.43) | RXRARXRBRXRGXPO1KMT2A | |
| SCHEMBL14995389 | 0.78 | RXRA (0.43) | RXRARXRBRXRGKMT2AMEN1 | |
| SCHEMBL14995358 | 0.78 | MARS1 (0.46) | RXRARXRBRXRGKMT2AMEN1 | |
| SCHEMBL14995553 | 0.77 | SLC5A1 (0.33) | MARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785705-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013079586-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2013-06-06 | — | — | WO | disclosed |