Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158351 | 0.80 | ALOX5 (0.42) | ALOX5SMN1; SMN2GSK3BNPC1RAB9A | |
| SCHEMBL9351950 | 0.75 | GSK3B (0.41) | ALOX5CYP2A6SMN1; SMN2GSK3BNPC1 | |
| SCHEMBL27673491 | 0.73 | LMNA (0.42) | ALOX5SMN1; SMN2GSK3BNPC1RAB9A | |
| SCHEMBL4775710 | 0.72 | GSK3B (0.43) | ALOX5CYP2A6SMN1; SMN2GSK3BNPC1 | |
| SCHEMBL10804734 | 0.71 | HPGD (0.41) | ALOX5SMN1; SMN2GSK3BNPC1RAB9A | |
| SCHEMBL827343 | 0.69 | — | — | |
| SCHEMBL5022912 | 0.68 | — | — | |
| SCHEMBL647119 | 0.68 | ELANE (0.39) | ALOX5SMN1; SMN2GSK3BNPC1RAB9A | |
| SCHEMBL1942869 | 0.67 | CYP2A6 (0.34) | ALOX5CYP2A6SMN1; SMN2GSK3BNPC1 | |
| SCHEMBL13665359 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | disclosed |