Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.58 |
| ▸ | CTSK | P43235 | 7/20 | 0.58 |
| ▸ | CTSB | P07858 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13731820 | 0.89 | CTSS (0.58) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL6800679 | 0.82 | ITGA4 (0.61) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL6800676 | 0.82 | ITGA4 (0.61) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL7064453 | 0.82 | BCHE (0.53) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL4420857 | 0.82 | ATM (0.55) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL10653891 | 0.81 | CTSS (0.51) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL8951298 | 0.81 | CTSS (0.73) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL17154025 | 0.80 | CTSS (0.51) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL10956368 | 0.79 | CTSS (0.48) | CTSSCTSKCTSBCTSLACE | |
| SCHEMBL19513108 | 0.78 | CTSS (0.70) | CTSSCTSKCTSBCTSLACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246136-A1 | NOVEL BINDER-DRUG CONJUGATES (ADCs) AND USE OF SAME | SEATTLE GENETICS, INC. (US) | 2015-09-03 | — | — | US | disclosed |
| US-8722629-B2 | Auristatin derivatives and use thereof | SEATTLE GENETICS, INC. (US) | 2014-05-13 | — | — | US | disclosed |
| US-20140127240-A1 | Novel Binder-Drug Conjugates (ADCs) and Use of Same | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-05-08 | — | — | US | disclosed |
| US-20130157960-A1 | NOVEL AURISTATIN DERIVATIVES AND USE THEREOF | SEATTLE GENETICS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140127240-A1 | Novel Binder-Drug Conjugates (ADCs) and Use of Same | DDR1, IGFBP6, KDR | CTSS 2162/4885CTSK 1706/4885CTSB 3324/4885 |
| US-20150246136-A1 | NOVEL BINDER-DRUG CONJUGATES (ADCs) AND USE OF SAME | DDR1, IGFBP6, KDR | CTSS 2162/4885CTSK 1706/4885CTSB 3324/4885 |
| US-20130157960-A1 | NOVEL AURISTATIN DERIVATIVES AND USE THEREOF | AURKC, AURKA, AURKB | CTSS 1956/4885CTSK 1143/4885CTSB 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.