Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 8/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.41 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.41 |
| ▸ | NDUFAB1 | O14561 | 1/20 | 0.41 |
| ▸ | NDUFA1 | O15239 | 1/20 | 0.41 |
| ▸ | NDUFS4 | O43181 | 1/20 | 0.41 |
| ▸ | NDUFB5 | O43674 | 1/20 | 0.41 |
| ▸ | NDUFB3 | O43676 | 1/20 | 0.41 |
| ▸ | NDUFC1 | O43677 | 1/20 | 0.41 |
| ▸ | NDUFA2 | O43678 | 1/20 | 0.41 |
| ▸ | NDUFS5 | O43920 | 1/20 | 0.41 |
| ▸ | NDUFS7 | O75251 | 1/20 | 0.41 |
| ▸ | NDUFS2 | O75306 | 1/20 | 0.41 |
| ▸ | NDUFS6 | O75380 | 1/20 | 0.41 |
| ▸ | NDUFB1 | O75438 | 1/20 | 0.41 |
| ▸ | NDUFS3 | O75489 | 1/20 | 0.41 |
| ▸ | NDUFB6 | O95139 | 1/20 | 0.41 |
| ▸ | NDUFA3 | O95167 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502360 | 1.00 | ALOX15 (0.41) | ALOX15TDP1KDM4ENDUFS8COXFA4 | |
| SCHEMBL1501829 | 0.81 | CYP11B1 (0.38) | KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL29466608 | 0.77 | CLK2 (0.37) | KDM4EALDH1A1CYP3A4MAPTHPGD | |
| SCHEMBL24183231 | 0.74 | ALOX15 (0.60) | ALOX15TDP1KDM4ENDUFS8COXFA4 | |
| SCHEMBL1502376 | 0.73 | CYP11B1 (0.46) | KDM4EALDH1A1 | |
| SCHEMBL4899475 | 0.71 | ALOX15 (0.54) | ALOX15TDP1KDM4ENDUFS8COXFA4 | |
| SCHEMBL4899481 | 0.71 | ALOX15 (0.54) | ALOX15TDP1KDM4ENDUFS8COXFA4 | |
| SCHEMBL1501932 | 0.71 | IDO1 (0.50) | — | |
| SCHEMBL24183240 | 0.70 | ALOX15 (0.55) | ALOX15TDP1KDM4ENDUFS8COXFA4 | |
| SCHEMBL7539831 | 0.70 | ALOX15 (0.47) | ALOX15TDP1KDM4ENDUFS8COXFA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174942-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140323740-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-10-30 | — | — | US | disclosed |
| US-8748469-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-06-10 | — | — | US | disclosed |
| US-20110136796-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2291187-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009132238-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323740-A1 | IDO Inhibitors | IDO1, IDO2, INMT | ALOX15 707/4885TDP1 1338/4885KDM4E 271/4885 |
| US-20110136796-A1 | IDO Inhibitors | IDO1, IDO2, INMT | ALOX15 707/4885TDP1 1338/4885KDM4E 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.