Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 2/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15023674 | 1.00 | SLC6A9 (0.41) | SLC6A9KCNH2GPR119ALDH1A1LMNA | |
| SCHEMBL15022674 | 0.93 | SLC6A9 (0.43) | SLC6A9KCNH2GPR119PTGS1PTGS2 | |
| SCHEMBL15022676 | 0.93 | SLC6A9 (0.43) | SLC6A9KCNH2GPR119PTGS1PTGS2 | |
| SCHEMBL15023673 | 0.90 | SLC6A9 (0.45) | SLC6A9KCNH2GPR119ALDH1A1LMNA | |
| SCHEMBL15022660 | 0.89 | GPR119 (0.43) | SLC6A9KCNH2GPR119PTGS1PTGS2 | |
| SCHEMBL15022658 | 0.89 | GPR119 (0.43) | SLC6A9KCNH2GPR119PTGS1PTGS2 | |
| SCHEMBL15022855 | 0.85 | SLC6A9 (0.46) | SLC6A9KCNH2GPR119ALDH1A1LMNA | |
| SCHEMBL15022856 | 0.85 | SLC6A9 (0.46) | SLC6A9KCNH2GPR119ALDH1A1LMNA | |
| SCHEMBL15022672 | 0.84 | SLC6A9 (0.45) | SLC6A9KCNH2GPR119PTGS1PTGS2 | |
| SCHEMBL15022865 | 0.82 | GPR119 (0.40) | SLC6A9GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754226-B2 | Piperidinyl-substituted lactams as GPR119 modulators | ARRAY BIOPHARMA INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20130158009-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158009-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | GPR119, GPR139, GPR39 | SLC6A9 324/4885KCNH2 1430/4885GPR119 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.