Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 3/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | KISS1R | Q969F8 | 4/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.31 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19472114 | 1.00 | TSHR (0.41) | TSHRALDH1A1TDP1RNPEPSLC7A5 | |
| SCHEMBL25751406 | 0.90 | TSHR (0.39) | TSHRALDH1A1TDP1CA2CA1 | |
| SCHEMBL16329147 | 0.79 | ALDH1A1 (0.39) | ALDH1A1TDP1RNPEPSLC7A5CA1 | |
| SCHEMBL13460878 | 0.77 | — | — | |
| SCHEMBL18265596 | 0.77 | — | — | |
| SCHEMBL13361506 | 0.77 | — | — | |
| SCHEMBL17943255 | 0.76 | SLC7A5 (0.54) | TSHRALDH1A1TDP1RNPEPSLC7A5 | |
| SCHEMBL13523611 | 0.76 | RNPEP (0.33) | TSHRRNPEPSLC7A5ANPEP | |
| SCHEMBL17640577 | 0.76 | TSHR (0.39) | TSHRALDH1A1TDP1RNPEPSLC7A5 | |
| SCHEMBL8088103 | 0.76 | SLC7A5 (0.54) | TSHRALDH1A1TDP1RNPEPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708341-B2 | Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof | AMGEN INC. | 2023-07-25 | — | — | US | disclosed |
| US-20230136796-A1 | Tripeptide Propylene Oxide Derivative and Preparation Method and Application thereof | SHENZHEN JIKANG PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2023-05-04 | — | — | US | disclosed |
| US-20170298093-A1 | Process for the Preparation of (S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-YL)-1-OXO Pentan-2-YL) Amino)-1-OXO-3-Phenylpropan-2-YL)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido) Pentanamide | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD (IN) | 2017-10-19 | — | — | US | disclosed |
| US-20160215016-A1 | SYNTHESIS OF PEPTIDE EPOXY KETONES | SANDOZ GMBH (AT) | 2016-07-28 | — | — | US | disclosed |
| US-20160215016-A1 | SYNTHESIS OF PEPTIDE EPOXY KETONES | SANDOZ GMBH (AT) | 2016-07-28 | — | — | US | disclosed |
| US-20160194354-A1 | STEREOSELECTIVE SYNTHESIS OF DIOLS AND TRIOLS BY MANNICH REACTION AND THEIR USE IN THE SYNTHESIS OF CARFILZOMIB | SANDOZ GMBH (AT) | 2016-07-07 | — | — | US | disclosed |
| US-9187442-B2 | Method for producing stereoselective epoxyketone compound | NISSAN CHEMICAL INDUSTIES, LTD. (JP) | 2015-11-17 | — | — | US | disclosed |
| US-20150126755-A1 | METHOD FOR PRODUCING STEREOSELECTIVE EPOXYKETONE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-05-07 | — | — | US | disclosed |
| US-8921324-B2 | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides | ONYX THERAPEUTICS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921583-B2 | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides | ONYX THERAPEUTICS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-20130150290-A1 | Crystalline Peptide Epoxy Ketone Protease Inhibitors and the Synthesis of Amino Acid Keto-Epoxides | ONYX THERAPEUTICS, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150289-A1 | Crystalline Peptide Epoxy Ketone Protease Inhibitors and the Synthesis of Amino Acid Keto-Epoxides | ONYX THERAPEUTICS, INC. (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298093-A1 | Process for the Preparation of (S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-YL)-1-OXO Pentan-2-YL) Amino)-1-OXO-3-Phenylpropan-2-YL)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido) Pentanamide | PSMA1, PSMA2, PSMA6 | TSHR 4199/4885ALDH1A1 2351/4885TDP1 2954/4885 |
| US-20150126755-A1 | METHOD FOR PRODUCING STEREOSELECTIVE EPOXYKETONE COMPOUND | HSD17B7, CYP51A1, AKR1B10 | TSHR 3180/4885ALDH1A1 331/4885TDP1 4552/4885 |
| US-20160194354-A1 | STEREOSELECTIVE SYNTHESIS OF DIOLS AND TRIOLS BY MANNICH REACTION AND THEIR USE IN THE SYNTHESIS OF CARFILZOMIB | PAICS, MANBA, MAN2A1 | TSHR 4375/4885ALDH1A1 2822/4885TDP1 3527/4885 |
| US-20130150290-A1 | Crystalline Peptide Epoxy Ketone Protease Inhibitors and the Synthesis of Amino Acid Keto-Epoxides | PREP, ANPEP, DNPEP | TSHR 4054/4885ALDH1A1 3400/4885TDP1 3731/4885 |
| US-20230136796-A1 | Tripeptide Propylene Oxide Derivative and Preparation Method and Application thereof | PSMB1, PSMB11, PSMB3 | TSHR 2251/4885ALDH1A1 3607/4885TDP1 2394/4885 |
| US-20160215016-A1 | SYNTHESIS OF PEPTIDE EPOXY KETONES | VIP, PTMS, EPOR | TSHR 3481/4885ALDH1A1 3590/4885TDP1 4441/4885 |
| US-11708341-B2 | Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof | EPOR, KDM5A, PSMA5 | TSHR 4308/4885ALDH1A1 800/4885TDP1 2854/4885 |
| US-20130150289-A1 | Crystalline Peptide Epoxy Ketone Protease Inhibitors and the Synthesis of Amino Acid Keto-Epoxides | PREP, ANPEP, DNPEP | TSHR 4054/4885ALDH1A1 3400/4885TDP1 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.