Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | FOS | P01100 | 4/20 | 0.37 |
| ▸ | JUN | P05412 | 4/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.37 |
| ▸ | RELA | Q04206 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.33 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15026115 | 0.86 | KDM4E (0.38) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL12429200 | 0.81 | TRPM8 (0.40) | TRPM8FOSJUNNFKB1NFKB2 | |
| SCHEMBL15026119 | 0.79 | TEAD2 (0.39) | CYP2C19ADORA3TEAD2ADORA2AADORA1 | |
| SCHEMBL15026117 | 0.79 | TEAD2 (0.33) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL18149668 | 0.72 | FOS (0.38) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL31714850 | 0.71 | IKBKB (0.44) | TEAD2KDM4EALDH1A1HTTHSD17B10 | |
| SCHEMBL13860366 | 0.70 | L3MBTL1 (0.43) | CYP3A4CYP2C19KDM4EALDH1A1HTT | |
| SCHEMBL18131164 | 0.68 | L3MBTL1 (0.36) | KDM4EALDH1A1HTTNPC1RAB9A | |
| SCHEMBL8696094 | 0.68 | TEAD2 (0.38) | TEAD2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL8696070 | 0.67 | LMNA (0.40) | CYP2C19TEAD2KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130150350-A1 | Derivatives of 1-Phenyl-1,5-Dihydro-Benzo[B] [1,4]Diazepine-2,4-Dione as Inhibitors of HIV Replication | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150350-A1 | Derivatives of 1-Phenyl-1,5-Dihydro-Benzo[B] [1,4]Diazepine-2,4-Dione as Inhibitors of HIV Replication | MED1, ZC3HAV1, BET1 | TRPM8 4460/4885FOS 3262/4885JUN 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.