Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.69 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL27414288 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL29985333 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL725567 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL6686451 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL725565 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL31084206 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL2425697 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2425693 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL4455489 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28502951 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 235 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12391591-B2 | Process cooling water system control systems and methods for iron and steelmaking applications | CHEMTREAT, INC. (US) | 2025-08-19 | — | — | US | claimed |
| CN-119949306-A | Suspension containing tricyclazole and preparation method and application thereof | 沈阳中化农药化工研发有限公司 | 2025-05-09 | — | — | CN | claimed |
| EP-4301570-B1 | METHOD FOR DECOLORING OF A TEXTILE MATERIAL | SOEDRA SKOGSAEGARNA EKONOMISK FOERENING (SE) | 2025-04-23 | — | — | EP | claimed |
| CN-119081731-A | Crude oil demetallization method and pre-removal agent and demetallization agent adopted by method | 金浦新材料股份有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-118639282-B | Tin spraying solution, preparation method thereof and application of tin spraying solution in spraying process | 昆山一鼎工业科技有限公司 | 2024-11-26 | — | — | CN | claimed |
| CN-118725610-A | Preparation method and application of heavy calcium carbonate based on surface multicomponent | 天津理工大学 | 2024-10-01 | — | — | CN | claimed |
| CN-118639282-A | Tin spraying solution, preparation method thereof and application of tin spraying solution in spraying process | 昆山一鼎工业科技有限公司 | 2024-09-13 | — | — | CN | claimed |
| CN-118496718-A | Corrosion-resistant and high-temperature-resistant steel-lined tetrafluoro storage tank and preparation method thereof | 江苏亚氟隆防腐科技有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-118497767-A | Low-metal-ion-residue chip post-CMP cleaning agent and preparation method and application thereof | 浙江奥首材料科技有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-118360110-A | Special strong scale-resistant detergent composition for dish-washing machine and preparation method thereof | 佛山市顺德区美的洗涤电器制造有限公司 | 2024-07-19 | — | — | CN | claimed |
| CN-111733588-B | Knitted fabric printing and dyeing pretreatment liquid, preparation method and knitted fabric dyeing process | 台州同兴印染有限公司 | 2022-10-25 | — | — | CN | claimed |
| CN-115058716-A | Neutral water-based metal cleaning solution | 南京科润新材料技术有限公司 | 2022-09-16 | — | — | CN | claimed |
| WO-2022186754-A1 | METHOD FOR DECOLORING OF A TEXTILE MATERIAL | SÖDRA SKOGSÄGARNA EKONOMISK FÖRENING (SE) | 2022-09-09 | — | — | WO | claimed |
| CN-114854504-A | Special detergent composition for high-efficiency dish-washing machine | 佛山市顺德区美的洗涤电器制造有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-114854503-A | Detergent composition for removing stubborn stains special for dish washing machine | 佛山市顺德区美的洗涤电器制造有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-114806753-A | Linen detergent | 华南师范大学 | 2022-07-29 | — | — | CN | claimed |
| CN-114773043-A | High-strength ceramic material, processing technology and high-strength ceramic tile | 河北新玻尔瓷业有限公司 | 2022-07-22 | — | — | CN | claimed |
| CN-114774209-A | Special detergent composition for household automatic dish-washing machine | 佛山市顺德区美的洗涤电器制造有限公司 | 2022-07-22 | — | — | CN | claimed |
| CN-114425377-A | Ortho-phthalaldehyde catalyst, preparation method and application | 中国石油化工股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-114410205-A | Anion solution with super-strong antibacterial effect and preparation method thereof | 广州好名堂健康产业有限公司 | 2022-04-29 | — | — | CN | claimed |