Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.69 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1502680 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL27414288 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL29985333 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL6686451 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL725565 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL31084206 | 1.00 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL2425697 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2425693 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL4455489 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28502951 | 0.96 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 562 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119685938-A | TOPCon battery monocrystalline silicon alkali polishing additive and application method thereof | 合肥中聚和成电子材料有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-118724057-A | Preparation method of magnesium-doped lithium lanthanum zirconium tantalum oxide solid electrolyte | 江苏新锂元科技有限公司 | 2024-10-01 | — | — | CN | claimed |
| CN-118291104-A | Blocking well wall stabilizing treatment agent, preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-05 | — | — | CN | claimed |
| CN-117822028-A | Nest-shaped electrode and preparation method and application thereof | 邯郸市科领新材料有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-114395815-B | Rare earth antibacterial acrylic fiber and preparation method thereof | 镧明材料技术(上海)有限公司 | 2024-01-12 | — | — | CN | claimed |
| CN-116621658-B | Nitrogen-phosphorus synergistic agent composition and application thereof | 中化现代农业有限公司 | 2023-10-31 | — | — | CN | claimed |
| CN-114433205-B | Preparation method of bulk phase hydrocracking catalyst | 中国石油化工股份有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-116621658-A | Nitrogen-phosphorus synergistic agent composition and application thereof | 中化现代农业有限公司 | 2023-08-22 | — | — | CN | claimed |
| CN-116554969-A | Laundry detergent for infants and preparation method thereof | 西安优露清科技股份有限公司 | 2023-08-08 | — | — | CN | claimed |
| CN-115281188-B | Preparation method and application of suspending agent containing water-soluble herbicide | 浙江新安化工集团股份有限公司 | 2023-05-19 | — | — | CN | claimed |
| CN-102911805-B | Method for preparing novel efficient soaping agent for activated dyes | NANJING DADI REFRIGERATION FOOD CO LTD | 2014-02-26 | — | — | CN | claimed |
| CN-103189149-A | Method for coating surfaces and use of the articles coated using said method | CHEMETALL GMBH | 2013-07-03 | — | — | CN | claimed |
| CN-102911805-A | Method for preparing novel efficient soaping agent for activated dyes | NANJING DADI REFRIGERATION FOOD CO LTD | 2013-02-06 | — | — | CN | claimed |
| CN-101503860-B | Wet friction fastness improving agent for dyeing fabric | SHANGHAI DAWNSUN FINE CHEMICAL CO LTD | 2012-09-05 | — | — | CN | claimed |
| US-8252296-B2 | Aqueous polymer dispersion and use thereof in cosmetics | BASF SE (DE) | 2012-08-28 | — | — | US | claimed |
| CN-101001942-A | Process for preparing granular detergent composition having improved solubility | PROCTER & GAMBLE (US) | 2007-07-18 | — | — | CN | claimed |
| US-5750489-A | SURFACTANTS, DEFLOCCULATING POLYMER, IONIC POLYMER | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1998-05-12 | — | — | US | claimed |
| EP-0262649-B1 | Method of preparing blends of incompatible hydrocarbon polymers | UNION CARBIDE CORP (US) | 1994-12-14 | — | — | EP | claimed |
| CN-85109162-A | Prepare method of perfluoroalkyl vinyl polymkeric substance and uses thereof | — | 1986-10-01 | — | — | CN | claimed |
| US-3990980-A | Hybrid liquid toners | PHILIP A. HUNT CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | claimed |