Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1502680 | 0.96 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL29985333 | 0.96 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL725565 | 0.96 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL725567 | 0.96 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL6686451 | 0.96 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL31084206 | 0.96 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL27414288 | 0.96 | LMNA (0.77) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL2425693 | 0.93 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28495385 | 0.93 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL2425697 | 0.93 | LMNA (0.71) | LMNATSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11971510-B2 | Gel dosimeter for measuring radiation dose | RIKEN (JP) | 2024-04-30 | — | — | US | disclosed |
| US-11960038-B2 | Radiation dosimetry gel and radiation dosimeter comprising same as material for measuring radiation dose | RIKEN (JP) | 2024-04-16 | — | — | US | disclosed |
| US-20240012165-A1 | GEL DOSIMETER FOR MEASURING RADIATION DOSE | RIKEN (JP) | 2024-01-11 | — | — | US | disclosed |
| CN-109196384-B | Gel-forming composition for radiation dosimetry, and radiation dosimeter using gel formed from the composition | 国立研究开发法人理化学研究所 | 2023-07-18 | — | — | CN | disclosed |
| US-20220221594-A1 | RADIATION DOSIMETRY GEL AND RADIATION DOSIMETER COMPRISING SAME AS MATERIAL FOR MEASURING RADIATION DOSE | RIKEN (JP) | 2022-07-14 | — | — | US | disclosed |
| US-11150358-B2 | Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry | RIKEN (JP) | 2021-10-19 | — | — | US | disclosed |
| US-20200333474-A1 | RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER COMPRISING SAME AS MATERIAL FOR RADIATION DOSIMETRY | RIKEN (JP) | 2020-10-22 | — | — | US | disclosed |
| EP-3686632-A1 | RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER COMPRISING SAME AS MATERIAL FOR RADIATION DOSIMETRY | Riken (JP) | 2020-07-29 | — | — | EP | disclosed |
| US-20090017298-A1 | Adhesive composition, adhesive optical film and image display device | NITTO DENKO CORPORATION (JP) | 2009-01-15 | — | — | US | disclosed |